@article{oai:repo.qst.go.jp:00047762,
 author = {Ito, Hiroshi and Takuwa, Hiroyuki and Tajima, Yosuke and Kawaguchi, Hiroshi and Urushihata, Takuya and Taniguchi, Junko and Ikoma, Yoko and Seki, Chie and Ibaraki, Masanobu and Masamoto, Kazuto and Kanno, Iwao and 伊藤 浩 and 田桑 弘之 and 川口 拓之 and 漆畑 拓弥 and 生駒 洋子 and 関 千江 and 茨木 正信 and 正本 和人 and 菅野 巖},
 issue = {2},
 journal = {The journal of physiological sciences : JPS},
 month = {Jun},
 note = {The relation between cerebral blood flow (CBF) and cerebral oxygen extraction fraction (OEF) can be expressed using the effective diffusivity for oxygen in the capillary bed (D) as OEF = 1 - exp(-D/CBF). The D value is proportional to the microvessel blood volume. In this study, changes in D during neural activation and deactivation were estimated from changes in capillary and arteriole diameter measured by two-photon microscopy in awake mice. Capillary and arteriole vessel diameter in the somatosensory cortex and cerebellum were measured under neural activation (sensory stimulation) and neural deactivation [crossed cerebellar diaschisis (CCD)], respectively. Percentage changes in D during sensory stimulation and CCD were 10.3 ± 7.3 and -17.5 ± 5.3 % for capillary diameter of <6 μm, respectively. These values were closest to the percentage changes in D calculated from previously reported human positron emission tomography data. This may indicate that thinner capillaries might play the greatest role in oxygen transport from blood to brain tissue.},
 pages = {325--330},
 title = {Changes in effective diffusivity for oxygen during neural activation and deactivation estimated from capillary diameter measured by two-photon laser microscope.},
 volume = {67},
 year = {2016}
}