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Synthesis and Antioxidant Activity of a Procyanidin B3 Analogue
https://repo.qst.go.jp/records/47707
https://repo.qst.go.jp/records/477072fabcf71-7006-4a8e-a53e-4fdc1382d4ed
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-04-19 | |||||
| タイトル | ||||||
| タイトル | Synthesis and Antioxidant Activity of a Procyanidin B3 Analogue | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Mizuno, Mirei
× Mizuno, Mirei× Nakanishi, Ikuo× Matsubayashi, Satoko× Imai, Kohei× Arai, Takuya× Matsumoto, Kenichiro× Fukuhara, Kiyoshi× 中西 郁夫× 今井 耕平× 荒井 卓也× 松本 謙一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Proanthocyanidin, an oligomer of catechin, is a natural antioxidant and a potent inhibitor of lectin-like oxidized LDL receptor-1, which is involved in the pathogenesis of arteriosclerosis. We synthesized proanthocyanidin analogue 1, in which the geometry of one catechin molecule in procyanidin B3, a dimer of (+)-catechin, is constrained to be planar. The antioxidant activities of the compounds were evaluated in terms of their capacities to scavenge galvinoxyl radicals, and results demonstrate that while procyanidin was 3.8 times more potent than (+)-catechin, the radical scavenging activity of proanthocyanidin analogue 1 was further increased to 1.9 times that of procyanidin B3. This newly designed proanthocyanidin analogue 1 may be a promising lead compound for the treatment of arteriosclerosis and related cerebrovascular diseases. | |||||
| 書誌情報 |
Bioorganic & Medicinal Chemistry Letters 巻 27, 号 4, p. 1041-1044, 発行日 2016-12 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0960-894X | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 28082039 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.bmcl.2016.12.067 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.sciencedirect.com/science/article/pii/S0960894X16313403 | |||||
| 関連名称 | http://www.sciencedirect.com/science/article/pii/S0960894X16313403 | |||||
