@article{oai:repo.qst.go.jp:00047707,
 author = {Mizuno, Mirei and Nakanishi, Ikuo and Matsubayashi, Satoko and Imai, Kohei and Arai, Takuya and Matsumoto, Kenichiro and Fukuhara, Kiyoshi and 中西 郁夫 and 今井 耕平 and 荒井 卓也 and 松本 謙一郎},
 issue = {4},
 journal = {Bioorganic & Medicinal Chemistry Letters},
 month = {Dec},
 note = {Proanthocyanidin, an oligomer of catechin, is a natural antioxidant and a potent inhibitor of lectin-like oxidized LDL receptor-1, which is involved in the pathogenesis of arteriosclerosis. We synthesized proanthocyanidin analogue 1, in which the geometry of one catechin molecule in procyanidin B3, a dimer of (+)-catechin, is constrained to be planar. The antioxidant activities of the compounds were evaluated in terms of their capacities to scavenge galvinoxyl radicals, and results demonstrate that while procyanidin was 3.8 times more potent than (+)-catechin, the radical scavenging activity of proanthocyanidin analogue 1 was further increased to 1.9 times that of procyanidin B3. This newly designed proanthocyanidin analogue 1 may be a promising lead compound for the treatment of arteriosclerosis and related cerebrovascular diseases.},
 pages = {1041--1044},
 title = {Synthesis and Antioxidant Activity of a Procyanidin B3 Analogue},
 volume = {27},
 year = {2016}
}