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Simple and effective method for producing [11C]phosgene using an environmental CCl4 gas detection tube
https://repo.qst.go.jp/records/47686
https://repo.qst.go.jp/records/47686ed46743b-9476-48cc-9cbb-fba8dec9b5fa
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-03-27 | |||||
| タイトル | ||||||
| タイトル | Simple and effective method for producing [11C]phosgene using an environmental CCl4 gas detection tube | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ogawa, Masanao
× Ogawa, Masanao× Takada, Yuuki× Suzuki, Hisashi× Nemoto, Kazuyoshi× Fukumura, Toshimitsu× 小川 政直× 高田 由貴× 鈴木 寿× 根本 和義× 福村 利光 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Abstract Introduction Carbon-11-labeled phosgene is an important labeling precursor for PET molecular probes. Despite the usefulness of [11C]phosgene, some difficulties, especially in the formation of [11C]phosgene process from [11C]CCl4, hamper its use. The present article shows a simple preparation method for [11C]phosgene. Method [11C]CCl4 was obtained using the conventional method by passing a mixture of [11C]CH4 and Cl2 through a heated quartz tube. The [11C]CCl4 was transformed to [11C]phosgene simply by passing through a pretreatment tube of a Kitagawa gas detection system for the working-environmental CCl4 concentration measurement at room temperature with a flow rate of 50 ml/min. Result This tube successfully transformed [11C]CCl4 to [11C]phosgene at room temperature. [11C]Phosgene was obtained at nearly 80% radiochemical yield (EOB) in a short synthesis time with high reproducibility. Conclusion A high yield and reliable [11C]phosgene production method using a gas detector tube system for working-environmental CCl4 concentration measurement was developed. |
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| 書誌情報 |
Nuclear Medicine and Biology 巻 37, 号 1, p. 73-76, 発行日 2010-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0969-8051 | |||||
