@article{oai:repo.qst.go.jp:00047686,
 author = {Ogawa, Masanao and Takada, Yuuki and Suzuki, Hisashi and Nemoto, Kazuyoshi and Fukumura, Toshimitsu and 小川 政直 and 高田 由貴 and 鈴木 寿 and 根本 和義 and 福村 利光},
 issue = {1},
 journal = {Nuclear Medicine and Biology},
 month = {Jan},
 note = {Abstract
Introduction
Carbon-11-labeled phosgene is an important labeling precursor for PET molecular probes. Despite the usefulness of [11C]phosgene, some difficulties, especially in the formation of [11C]phosgene process from [11C]CCl4, hamper its use. The present article shows a simple preparation method for [11C]phosgene.
Method
[11C]CCl4 was obtained using the conventional method by passing a mixture of [11C]CH4 and Cl2 through a heated quartz tube. The [11C]CCl4 was transformed to [11C]phosgene simply by passing through a pretreatment tube of a Kitagawa gas detection system for the working-environmental CCl4 concentration measurement at room temperature with a flow rate of 50 ml/min.
Result
This tube successfully transformed [11C]CCl4 to [11C]phosgene at room temperature. [11C]Phosgene was obtained at nearly 80% radiochemical yield (EOB) in a short synthesis time with high reproducibility.
Conclusion
A high yield and reliable [11C]phosgene production method using a gas detector tube system for working-environmental CCl4 concentration measurement was developed.},
 pages = {73--76},
 title = {Simple and effective method for producing [11C]phosgene using an environmental CCl4 gas detection tube},
 volume = {37},
 year = {2010}
}