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Radiosynthesis of [2-11C-carbonyl]dantrolene using [11C]phosgene for PET
https://repo.qst.go.jp/records/47685
https://repo.qst.go.jp/records/47685fd565577-3ff7-4714-9706-2706b5cff40e
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-03-27 | |||||
タイトル | ||||||
タイトル | Radiosynthesis of [2-11C-carbonyl]dantrolene using [11C]phosgene for PET | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Takada, Yuuki
× Takada, Yuuki× Ogawa, Masanao× Suzuki, Hisashi× Fukumura, Toshimitsu× 高田 由貴× 小川 政直× 鈴木 寿× 福村 利光 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Automated radiosynthesis of [2-11C-carbonyl]dantrolene, the substrate of breast cancer resistance protein (BCRP/ABCG2), was performed for the first time through a multi-step/one-pot labeling sequence that started with ethyl 2-{2-[5-(4-nitrophenyl)furfurylidene]hydrazino}acetate and used [11C]phosgene as a labeling agent. After optimization of the automated synthesis conditions and parameters, [2-11Ccarbonyl] dantrolene was obtained at a radiochemical yield of 34.078.4% (decay-corrected). The radiochemical purity was greater than 98% and the specific activity was 46.8715.2 GBq/mmol at the end of the synthesis. |
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書誌情報 |
Applied Radiation and Isotopes 巻 68, 号 9, p. 1715-1720, 発行日 2010-09 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0969-8043 |