@article{oai:repo.qst.go.jp:00047685, author = {Takada, Yuuki and Ogawa, Masanao and Suzuki, Hisashi and Fukumura, Toshimitsu and 高田 由貴 and 小川 政直 and 鈴木 寿 and 福村 利光}, issue = {9}, journal = {Applied Radiation and Isotopes}, month = {Sep}, note = {Automated radiosynthesis of [2-11C-carbonyl]dantrolene, the substrate of breast cancer resistance protein (BCRP/ABCG2), was performed for the first time through a multi-step/one-pot labeling sequence that started with ethyl 2-{2-[5-(4-nitrophenyl)furfurylidene]hydrazino}acetate and used [11C]phosgene as a labeling agent. After optimization of the automated synthesis conditions and parameters, [2-11Ccarbonyl] dantrolene was obtained at a radiochemical yield of 34.078.4% (decay-corrected). The radiochemical purity was greater than 98% and the specific activity was 46.8715.2 GBq/mmol at the end of the synthesis.}, pages = {1715--1720}, title = {Radiosynthesis of [2-11C-carbonyl]dantrolene using [11C]phosgene for PET}, volume = {68}, year = {2010} }