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Radiolabeling of aromatic compounds using K[*Cl]Cl and OXONE
https://repo.qst.go.jp/records/47672
https://repo.qst.go.jp/records/47672d58f3615-892e-4491-bb21-380260c43485
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-03-21 | |||||
| タイトル | ||||||
| タイトル | Radiolabeling of aromatic compounds using K[*Cl]Cl and OXONE | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takada, Yuuki
× Takada, Yuuki× Hanyu, Masayuki× Nagatsu, Koutarou× Fukumura, Toshimitsu× 高田 由貴× 破入 正行× 永津 弘太郎× 福村 利光 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We report a novel labeling method for the rapid radiochlorination of aromatic compounds using no-carrier-added short half-life radioactive chloride ions ([38,39Cl]Cl-and [34mCl]Cl-) and OXONE (Sigma-Aldrich, Japan) as an oxidation reagent.The reaction of radioactive chloride ions with anisole in the presence of OXONE gave a mixture of p-[*Cl]chloroanisole and o-[*Cl]-chloroanisole, with a radiochemical conversion yield ofmore than 85%(not decay corrected) and selectivity of 7:3,within 10 min. Regioselective radioactive chlorination was achieved by chlorodestannylation of tributylstannyl compounds to afford the corresponding radiochlorinated compounds (p-chloroanisole and m-chloroanisole) in satisfactory radiochemical yields (80–95% and 46–65%, respectively). | |||||
| 書誌情報 |
Journal of Labelled Compounds & Radiopharmaceuticals 巻 55, 号 10, p. 383-386, 発行日 2012-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0362-4803 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/jlcr.2957 | |||||
