@article{oai:repo.qst.go.jp:00047672, author = {Takada, Yuuki and Hanyu, Masayuki and Nagatsu, Koutarou and Fukumura, Toshimitsu and 高田 由貴 and 破入 正行 and 永津 弘太郎 and 福村 利光}, issue = {10}, journal = {Journal of Labelled Compounds & Radiopharmaceuticals}, month = {Aug}, note = {We report a novel labeling method for the rapid radiochlorination of aromatic compounds using no-carrier-added short half-life radioactive chloride ions ([38,39Cl]Cl-and [34mCl]Cl-) and OXONE (Sigma-Aldrich, Japan) as an oxidation reagent.The reaction of radioactive chloride ions with anisole in the presence of OXONE gave a mixture of p-[*Cl]chloroanisole and o-[*Cl]-chloroanisole, with a radiochemical conversion yield ofmore than 85%(not decay corrected) and selectivity of 7:3,within 10 min. Regioselective radioactive chlorination was achieved by chlorodestannylation of tributylstannyl compounds to afford the corresponding radiochlorinated compounds (p-chloroanisole and m-chloroanisole) in satisfactory radiochemical yields (80–95% and 46–65%, respectively).}, pages = {383--386}, title = {Radiolabeling of aromatic compounds using K[*Cl]Cl and OXONE}, volume = {55}, year = {2012} }