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Genetic Variants of NPAT-ATM and AURKA are Associated with an Early Adverse Reaction in the Gastrointestinal Tract of Patients with Cervical Cancer Treated with Pelvic Radiation Therapy
https://repo.qst.go.jp/records/47661
https://repo.qst.go.jp/records/47661d5da4387-bb10-4ce5-be30-73e3ea4c9eac
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-03-15 | |||||
| タイトル | ||||||
| タイトル | Genetic Variants of NPAT-ATM and AURKA are Associated with an Early Adverse Reaction in the Gastrointestinal Tract of Patients with Cervical Cancer Treated with Pelvic Radiation Therapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ishikawa, Atsuko
× Ishikawa, Atsuko× Suga, Tomo× Shoji, Yoshimi× Kato, Shingo× Ohno, Tatsuya× Ishikawa, Hitoshi× Yoshinaga, Shinji× Ohara, Kiyoshi× Ariga, Hisanori× Nomura, Kuninori× Shibamoto, Yuta× Ishikawa, Kenichi× Moritake, Takashi× Michikawa, Yuichi× Iwakawa, Mayumi× Imai, Takashi× 石川 敦子× 菅 智× 荘司 好美× 加藤 眞吾× 大野 達也× 石川 仁× 吉永 信治× 大原 潔× 有賀 久哲× 野村 邦紀× 芝本 雄太× 石川 顕一× 盛武 敬× 道川 祐市× 岩川 眞由美× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: This study sought to associate polymorphisms in genes related to cell cycle regulation or genome maintenance with radiotherapy (RT)-induced an early adverse reaction (EAR) in patients with cervical cancer. Methods and Materials: This study enrolled 243 cervical cancer patients who were treated with pelvic RT. An early gastrointestinal reaction was graded using the National Cancer Institute Common Toxicity Criteria, version 2. Clinical factors of the enrolled patients were analyzed, and 208 patients were grouped for genetic analysis according to their EAR (Grade <= 1, n = 150; Grade <= 2, n = 58). Genomic DNAwas genotyped, and association with the risk of EAR for 44 functional single-nucleotide polymorphisms (SNPs) of 19 candidate genes was assessed by single-locus, haplotype, and multilocus analyses. Results: Our analysis revealed two haplotypes to be associated with an increased risk of EAR. The first, comprising rs625120C, rs189037T, rs228589A, and rs183460G, is located between the 5' ends of NPAT and ATM (OR = 1.86; 95% CI, 1.21-2.87), whereas the second is located in the AURKA gene and comprises rs2273535A and rs1047972G (OR = 1.75; 95% CI, 1.10-2.78). A third haplotype, rs2273535T and rs1047972A in AURKA, was associated with a reduced EAR risk (OR = 0.42; 95% CI, 0.20-0.89). The risk of EAR was significantly higher among patients with both risk diplotypes than in those possessing the other diplotypes (OR = 3.24; 95% CI, 1.52-6.92). Conclusions: Individual radiosensitivity of intestine may be determined by haplotypes in the NPAT-ATM and AURKA genes. These variants should be explored in larger association studies in cervical cancer patients. |
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| 書誌情報 |
International Journal of Radiation Oncology Biology Physics 巻 81, 号 4, p. 1144-1152, 発行日 2010-11 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0360-3016 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.ijrobp.2010.09.012 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.redjournal.org/article/S0360-3016%2810%2903260-8/abstract | |||||
| 関連名称 | http://www.redjournal.org/article/S0360-3016%2810%2903260-8/abstract | |||||
