@article{oai:repo.qst.go.jp:00047661,
 author = {Ishikawa, Atsuko and Suga, Tomo and Shoji, Yoshimi and Kato, Shingo and Ohno, Tatsuya and Ishikawa, Hitoshi and Yoshinaga, Shinji and Ohara, Kiyoshi and Ariga, Hisanori and Nomura, Kuninori and Shibamoto, Yuta and Ishikawa, Kenichi and Moritake, Takashi and Michikawa, Yuichi and Iwakawa, Mayumi and Imai, Takashi and 石川 敦子 and 菅 智 and 荘司 好美 and 加藤 眞吾 and 大野 達也 and 石川 仁 and 吉永 信治 and 大原 潔 and 有賀 久哲 and 野村 邦紀 and 芝本 雄太 and 石川 顕一 and 盛武 敬 and 道川 祐市 and 岩川 眞由美 and 今井 高志},
 issue = {4},
 journal = {International Journal of Radiation Oncology Biology Physics},
 month = {Nov},
 note = {Purpose: This study sought to associate polymorphisms in genes related to cell cycle regulation or genome maintenance with radiotherapy (RT)-induced an early adverse reaction (EAR) in patients with cervical cancer.
Methods and Materials: This study enrolled 243 cervical cancer patients who were treated with pelvic RT. An early gastrointestinal reaction was graded using the National Cancer Institute Common Toxicity Criteria, version 2. Clinical factors of the enrolled patients were analyzed, and 208 patients were grouped for genetic analysis according to their EAR (Grade <= 1, n = 150; Grade <= 2, n = 58). Genomic DNAwas genotyped, and association with the risk of EAR for 44 functional single-nucleotide polymorphisms (SNPs) of 19 candidate genes was assessed by single-locus, haplotype, and multilocus analyses.
Results: Our analysis revealed two haplotypes to be associated with an increased risk of EAR. The first, comprising rs625120C, rs189037T, rs228589A, and rs183460G, is located between the 5' ends of NPAT and ATM (OR = 1.86; 95% CI, 1.21-2.87), whereas the second is located in the AURKA gene and comprises rs2273535A and rs1047972G
(OR = 1.75; 95% CI, 1.10-2.78). A third haplotype, rs2273535T and rs1047972A in AURKA, was associated with a reduced EAR risk (OR = 0.42; 95% CI, 0.20-0.89). The risk of EAR was significantly higher among patients with both risk diplotypes than in those possessing the other diplotypes (OR = 3.24; 95% CI, 1.52-6.92).
Conclusions: Individual radiosensitivity of intestine may be determined by haplotypes in the NPAT-ATM and AURKA genes. These variants should be explored in larger association studies in cervical cancer patients.},
 pages = {1144--1152},
 title = {Genetic Variants of NPAT-ATM and AURKA are Associated with an Early Adverse Reaction in the Gastrointestinal Tract of Patients with Cervical Cancer Treated with Pelvic Radiation Therapy},
 volume = {81},
 year = {2010}
}