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  1. 原著論文

Carbon-ion radiotherapy for locally advanced cervical cancer with bladder invasion.

https://repo.qst.go.jp/records/47624
https://repo.qst.go.jp/records/47624
cf241e3d-bb4e-498f-8bd5-5ebd8d7f521d
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-01-30
タイトル
タイトル Carbon-ion radiotherapy for locally advanced cervical cancer with bladder invasion.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Shiba, Shintaro

× Shiba, Shintaro

WEKO 477426

Shiba, Shintaro

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Wakatsuki, Masaru

× Wakatsuki, Masaru

WEKO 477427

Wakatsuki, Masaru

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Kato, Shingo

× Kato, Shingo

WEKO 477428

Kato, Shingo

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Ohno, Tatsuya

× Ohno, Tatsuya

WEKO 477429

Ohno, Tatsuya

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Okonogi, Noriyuki

× Okonogi, Noriyuki

WEKO 477430

Okonogi, Noriyuki

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Karasawa, Kumiko

× Karasawa, Kumiko

WEKO 477431

Karasawa, Kumiko

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Kiyohara, Hiroki

× Kiyohara, Hiroki

WEKO 477432

Kiyohara, Hiroki

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Tsujii, Hirohiko

× Tsujii, Hirohiko

WEKO 477433

Tsujii, Hirohiko

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Nakano, Takashi

× Nakano, Takashi

WEKO 477434

Nakano, Takashi

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Kamada, Tadashi

× Kamada, Tadashi

WEKO 477435

Kamada, Tadashi

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Shozu, Makio

× Shozu, Makio

WEKO 477436

Shozu, Makio

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Working, Group of the Gynecological Tumor The

× Working, Group of the Gynecological Tumor The

WEKO 477437

Working, Group of the Gynecological Tumor The

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柴 慎太郎

× 柴 慎太郎

WEKO 477438

en 柴 慎太郎

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若月 優

× 若月 優

WEKO 477439

en 若月 優

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加藤 眞吾

× 加藤 眞吾

WEKO 477440

en 加藤 眞吾

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大野 達也

× 大野 達也

WEKO 477441

en 大野 達也

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小此木 範之

× 小此木 範之

WEKO 477442

en 小此木 範之

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唐澤 久美子

× 唐澤 久美子

WEKO 477443

en 唐澤 久美子

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清原 浩樹

× 清原 浩樹

WEKO 477444

en 清原 浩樹

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辻井 博彦

× 辻井 博彦

WEKO 477445

en 辻井 博彦

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中野 隆史

× 中野 隆史

WEKO 477446

en 中野 隆史

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鎌田 正

× 鎌田 正

WEKO 477447

en 鎌田 正

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抄録
内容記述タイプ Abstract
内容記述 The purpose of this study was to evaluate the efficacy and toxicities of carbon-ion radiotherapy (C-ion RT) for locally advanced cervical cancer with bladder invasion by a subset analysis of pooled data from eight prospective clinical trials at the National Institute of Radiological Sciences. Between June 1995 and January 2014, 29 patients with locally advanced cervical cancer with bladder invasion were identified. The median age was 56 years old (range 31-79 years old). The median tumor size at diagnosis on magnetic resonance imaging was 6.7 cm (range 3.5-11.0 cm). Histologically, 20 patients had squamous cell carcinoma and 9 had adenocarcinoma. C-ion RT was performed as a dose-escalation study in the initial trials. All patients received prophylactic whole-pelvic or extended-field irradiation and local boost. The total dose to the cervical tumor was 52.8-74.4 Gy (relative biological effectiveness) in 20 or 24 fractions. Weekly cisplatin (40 mg/m(2)/week, five cycles) was concurrently given to four patients. The median follow-up of all patients was 28.6 months (range 8.8-238.6 months). Grade 2 or higher late complications in the bladder were observed in eight patients, with seven developing vesicovaginal fistula. Six patients had Grade 2 or higher complications in the rectosigmoid colon. The 3-year overall survival rate was 47%, the 3-year local control rate was 66%, and the 3-year disease-free survival rate was 28%. In this study, C-ion RT showed favorable local control with reasonable toxicities, but the results were still unsatisfactory. We have the expectation of improvement of therapeutic effects by using C-ion RT with concurrent chemotherapy.
書誌情報 Journal of radiation research

巻 57, 号 6, p. 684-690, 発行日 2016-11
出版者
出版者 Oxford University Press
ISSN
収録物識別子タイプ ISSN
収録物識別子 0449-3060
PubMed番号
識別子タイプ PMID
関連識別子 27422932
DOI
識別子タイプ DOI
関連識別子 10.1093/jrr/rrw070
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