@article{oai:repo.qst.go.jp:00047624,
 author = {Shiba, Shintaro and Wakatsuki, Masaru and Kato, Shingo and Ohno, Tatsuya and Okonogi, Noriyuki and Karasawa, Kumiko and Kiyohara, Hiroki and Tsujii, Hirohiko and Nakano, Takashi and Kamada, Tadashi and Shozu, Makio and Working, Group of the Gynecological Tumor The and 柴 慎太郎 and 若月 優 and 加藤 眞吾 and 大野 達也 and 小此木 範之 and 唐澤 久美子 and 清原 浩樹 and 辻井 博彦 and 中野 隆史 and 鎌田 正},
 issue = {6},
 journal = {Journal of radiation research},
 month = {Nov},
 note = {The purpose of this study was to evaluate the efficacy and toxicities of carbon-ion radiotherapy (C-ion RT) for locally advanced cervical cancer with bladder invasion by a subset analysis of pooled data from eight prospective clinical trials at the National Institute of Radiological Sciences. Between June 1995 and January 2014, 29 patients with locally advanced cervical cancer with bladder invasion were identified. The median age was 56 years old (range 31-79 years old). The median tumor size at diagnosis on magnetic resonance imaging was 6.7 cm (range 3.5-11.0 cm). Histologically, 20 patients had squamous cell carcinoma and 9 had adenocarcinoma. C-ion RT was performed as a dose-escalation study in the initial trials. All patients received prophylactic whole-pelvic or extended-field irradiation and local boost. The total dose to the cervical tumor was 52.8-74.4 Gy (relative biological effectiveness) in 20 or 24 fractions. Weekly cisplatin (40 mg/m(2)/week, five cycles) was concurrently given to four patients. The median follow-up of all patients was 28.6 months (range 8.8-238.6 months). Grade 2 or higher late complications in the bladder were observed in eight patients, with seven developing vesicovaginal fistula. Six patients had Grade 2 or higher complications in the rectosigmoid colon. The 3-year overall survival rate was 47%, the 3-year local control rate was 66%, and the 3-year disease-free survival rate was 28%. In this study, C-ion RT showed favorable local control with reasonable toxicities, but the results were still unsatisfactory. We have the expectation of improvement of therapeutic effects by using C-ion RT with concurrent chemotherapy.},
 pages = {684--690},
 title = {Carbon-ion radiotherapy for locally advanced cervical cancer with bladder invasion.},
 volume = {57},
 year = {2016}
}