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Effects of chronic restraint-induced stress on radiation-induced chromosomal aberrations in mouse splenocytes
https://repo.qst.go.jp/records/47622
https://repo.qst.go.jp/records/47622e2874e4f-b5ec-4097-8475-563193543af9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-01-30 | |||||
| タイトル | ||||||
| タイトル | Effects of chronic restraint-induced stress on radiation-induced chromosomal aberrations in mouse splenocytes | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
勝部, 孝則
× 勝部, 孝則× 王, 冰× 田中, 薫× 二宮, 康晴× Ｇｕｉｌｌａｕｍｅ, Ｖａｒｅｓ× 川越, 大輝× 塩見, 尚子× 久保田, 善久× ＬＩＵ, Ｑｉａｎｇ× 森田, 明典× 中島, 徹夫× 根井, 充× 勝部 孝則× 王 冰× 田中 薫× 二宮 康晴× Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ× 川越 大輝× 塩見 尚子× 久保田 善久× ＬＩＵ Ｑｉａｎｇ× 中島 徹夫× 根井 充 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Both ionizing radiation (IR) and psychological stress (PS) cause detrimental effects on humans. A recent study showed that chronic restraint-induced PS (CRIPS) diminished the functions of Trp53 and enhanced radiocarcinogenesis in Trp53-heterozygous (Trp53+/-) mice. These findings had a marked impact on the academic field as well as the general public, particularly among residents living in areas radioactively contaminated by nuclear accidents. In an attempt to elucidate the modifying effects of CRIPS on radiation-induced health consequences in Trp53 wild-type (Trp53+/+) animals, investigations involving multidisciplinary analyses were performed. We herein demonstrated that CRIPS induced changes in the frequency of IR-induced chromosomal aberrations (CAs) in splenocytes. Five-week-old male Trp53+/+ C57BL/6J mice were restrained for 6 hours per day for 28 consecutive days, and total body irradiation (TBI) at a dose of 4 Gy was performed on the 8th day. Metaphase chromosome spreads prepared from splenocytes at the end of the 28-day restraint regimen were painted with fluorescence in situ hybridization (FISH) probes for chromosomes 1, 2, and 3. The results obtained showed that CRIPS alone did not induce CAs, while TBI caused significant increases in CAs, mostly translocations. Translocations appeared at a lower frequency in mice exposed to TBI plus CRIPS than in those exposed to TBI alone. No significant differences were observed in the frequencies of the other types of CAs (insertions, dicentrics, and fragments) visualized with FISH between these experimental groups (TBI+CRIPS vs. TBI). These results suggest that CRIPS does not appear to synergize with the clastogenicity of IR. | |||||
| 書誌情報 |
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 巻 813, p. 18-26, 発行日 2017-01 |
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| 出版者 | ||||||
| 出版者 | Elsevier B.V. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1383-5718 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.mrgentox.2016.11.005 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.1016/j.mrgentox.2016.11.005 | |||||
| 関連名称 | http://dx.doi.org/10.1016/j.mrgentox.2016.11.005 | |||||
