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Efficient preparation of high-quality 64Cu for routine use
https://repo.qst.go.jp/records/47565
https://repo.qst.go.jp/records/475656854a926-60d0-4f97-a2ec-b21f1952d74b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-10-12 | |||||
| タイトル | ||||||
| タイトル | Efficient preparation of high-quality 64Cu for routine use | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ohya, Tomoyuki
× Ohya, Tomoyuki× Nagatsu, Kotaro× Suzuki, Hisashi× Fukada, Masami× Minegishi, Katsuyuki× Hanyu, Masayuki× Fukumura, Toshimitsu× Zhang, Ming-Rong× 大矢 智幸× 永津 弘太郎× 鈴木 寿× 深田 正美× 峯岸 克行× 破入 正行× 福村 利光× 張 明栄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Introduction Copper-64 is an attractive radionuclide for positron emission tomography and is emerging as a radiotherapeutic agent. The demand of 64Cu with low metallic impurities has increased because of its wide applications when incorporated with antibodies, peptides, and proteins. In this study, we propose a new separation method to produce high-quality 64Cu using a cation exchange column, as well as an automated separation system suitable for large-scale production. \nMethods 64Cu was produced from an electrodeposited 64Ni target via the 64Ni(p,n)-reaction with a 24 MeV HH+ beam at 10 eμA (electrical microampere) conducted for 1–3 h. The irradiated target was transported to a hot cell and disassembled remotely. 64Cu was separated by a solvent mixture of HCl and acetone on a cation-exchange resin, AG50W-X8. The chemical purity of 64Cu final product was evaluated using ion-chromatography coupled with a UV detector and inductively coupled plasma mass spectroscopy for quality as well as metallic impurities. \nResults We obtained 64Cu in dried form at a yield of 5.2–13 GBq at the end of separation, or 521 ± 12 MBq/eμA h as the final product within 2.5 h of processing time. The metallic impurities were a satisfactory low level in the order of ppb. Major contaminants of Co and Ni were lower than those samples obtained by a widely accepted separation using an anion-exchange resin. \nConclusion Using a cation-exchange resin and a systematic operation, we successfully reduced the contamination level of the 64Cu product. As a straightforward separation method, which shortened the entire processing time, we obtained a satisfactory amount of high-quality 64Cu available for routine use. |
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| 書誌情報 |
Nuclear Medicine and Biology 巻 43, 号 11, p. 685-691, 発行日 2016-07 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.nucmedbio.2016.07.007 | |||||
