{"created":"2023-05-15T14:36:54.844890+00:00","id":47565,"links":{},"metadata":{"_buckets":{"deposit":"9d3039ef-622e-494d-a866-36c973d28750"},"_deposit":{"created_by":1,"id":"47565","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47565"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047565","sets":["1"]},"author_link":["476776","476786","476782","476775","476774","476777","476778","476784","476780","476785","476783","476773","476779","476781","476788","476787"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"691","bibliographicPageStart":"685","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"Nuclear Medicine and Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction\nCopper-64 is an attractive radionuclide for positron emission tomography and is emerging as a radiotherapeutic agent. The demand of 64Cu with low metallic impurities has increased because of its wide applications when incorporated with antibodies, peptides, and proteins. In this study, we propose a new separation method to produce high-quality 64Cu using a cation exchange column, as well as an automated separation system suitable for large-scale production.\n\\nMethods\n64Cu was produced from an electrodeposited 64Ni target via the 64Ni(p,n)-reaction with a 24 MeV HH+ beam at 10 eμA (electrical microampere) conducted for 1–3 h. The irradiated target was transported to a hot cell and disassembled remotely. 64Cu was separated by a solvent mixture of HCl and acetone on a cation-exchange resin, AG50W-X8. The chemical purity of 64Cu final product was evaluated using ion-chromatography coupled with a UV detector and inductively coupled plasma mass spectroscopy for quality as well as metallic impurities.\n\\nResults\nWe obtained 64Cu in dried form at a yield of 5.2–13 GBq at the end of separation, or 521 ± 12 MBq/eμA h as the final product within 2.5 h of processing time. The metallic impurities were a satisfactory low level in the order of ppb. Major contaminants of Co and Ni were lower than those samples obtained by a widely accepted separation using an anion-exchange resin.\n\\nConclusion\nUsing a cation-exchange resin and a systematic operation, we successfully reduced the contamination level of the 64Cu product. As a straightforward separation method, which shortened the entire processing time, we obtained a satisfactory amount of high-quality 64Cu available for routine use.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.nucmedbio.2016.07.007","subitem_relation_type_select":"DOI"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ohya, Tomoyuki"}],"nameIdentifiers":[{"nameIdentifier":"476773","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagatsu, Kotaro"}],"nameIdentifiers":[{"nameIdentifier":"476774","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Hisashi"}],"nameIdentifiers":[{"nameIdentifier":"476775","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukada, Masami"}],"nameIdentifiers":[{"nameIdentifier":"476776","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minegishi, Katsuyuki"}],"nameIdentifiers":[{"nameIdentifier":"476777","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hanyu, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"476778","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukumura, Toshimitsu"}],"nameIdentifiers":[{"nameIdentifier":"476779","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"476780","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大矢 智幸","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"476781","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"永津 弘太郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"476782","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 寿","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"476783","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"深田 正美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"476784","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"峯岸 克行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"476785","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"破入 正行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"476786","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福村 利光","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"476787","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"476788","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Efficient preparation of high-quality 64Cu for routine use","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Efficient preparation of high-quality 64Cu for routine use"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-10-12"},"publish_date":"2016-10-12","publish_status":"0","recid":"47565","relation_version_is_last":true,"title":["Efficient preparation of high-quality 64Cu for routine use"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:38:16.762834+00:00"}