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Induced pluripotent stem cell generation-associated point mutations
https://repo.qst.go.jp/records/47541
https://repo.qst.go.jp/records/47541e27852b7-c0bd-4cc3-9ae0-abe6c29685fe
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-09-06 | |||||
| タイトル | ||||||
| タイトル | Induced pluripotent stem cell generation-associated point mutations | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
R, Araki
× R, Araki× M, Sugiura× Y, Hoki× M, Sunayama× M, Nakamura× Y, Kasama× M, Abe× 荒木 良子× 杉浦 真由美× 藤森 ゆう子× 砂山 美里× 中村 美樹× 笠間 康次× 安倍 真澄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The discovery of induced pluripotent stem cells (iPSCs) has the potential to drastically alter the future of medicine. Further, the achievement of cell lineage conversion by gene transduction is expected to make a dramatic contribution to the advancement of basic biology. Currently, various iPSC applications have been the focus of much attention due to their potential in regenerative medicine. Nevertheless, because the molecular mechanisms underlying the creation of these cells have remained elusive, confidence in their safe use in a clinical setting has remained rather shaky. In our present review, we discuss genome integrity during iPSC generation, with a particular focus on point mutations, to further address the issue of whether iPSC generation causes genetic aberrations. | |||||
| 書誌情報 |
Inflammation and Regeneration 巻 35, 号 5, p. 226-232, 発行日 2015-11 |
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| 出版者 | ||||||
| 出版者 | the Japanese Society of Inflammation and Regeneration | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.jsir.gr.jp/journal/Vol35No5/3505.html | |||||
| 関連名称 | http://www.jsir.gr.jp/journal/Vol35No5/3505.html | |||||
