@article{oai:repo.qst.go.jp:00047541, author = {R, Araki and M, Sugiura and Y, Hoki and M, Sunayama and M, Nakamura and Y, Kasama and M, Abe and 荒木 良子 and 杉浦 真由美 and 藤森 ゆう子 and 砂山 美里 and 中村 美樹 and 笠間 康次 and 安倍 真澄}, issue = {5}, journal = {Inflammation and Regeneration}, month = {Nov}, note = {The discovery of induced pluripotent stem cells (iPSCs) has the potential to drastically alter the future of medicine. Further, the achievement of cell lineage conversion by gene transduction is expected to make a dramatic contribution to the advancement of basic biology. Currently, various iPSC applications have been the focus of much attention due to their potential in regenerative medicine. Nevertheless, because the molecular mechanisms underlying the creation of these cells have remained elusive, confidence in their safe use in a clinical setting has remained rather shaky. In our present review, we discuss genome integrity during iPSC generation, with a particular focus on point mutations, to further address the issue of whether iPSC generation causes genetic aberrations.}, pages = {226--232}, title = {Induced pluripotent stem cell generation-associated point mutations}, volume = {35}, year = {2015} }