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A primary role for nucleus accumbens and related limbic network in vocal tics
https://repo.qst.go.jp/records/47483
https://repo.qst.go.jp/records/47483859e13c6-8348-4bfd-b105-958e671a664c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-08-22 | |||||
| タイトル | ||||||
| タイトル | A primary role for nucleus accumbens and related limbic network in vocal tics | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
William, McCairn Kevin
× William, McCairn Kevin× Nagai, Yuji× Hori, Yukiko× Kikuchi, Erika× Ninomiya, Taihei× Suhara, Tetsuya× Lee, Ju-Young× Iriki, Atsushi× Minamimoto, Takafumi× Takada, Masahiko× Isoda, Masaki× Matsumoto, Masayuki× ＭｃＣａｉｒｎ Ｋｅｖｉｎ Ｗｉｌｌｉａｍ× 永井 裕司× 堀 由紀子× 菊池 瑛理佳× 須原 哲也× 南本 敬史× 松本 正幸 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Inappropriate vocal expressions - e.g., vocal tics in Tourette syndrome - severely impact quality of life. Neural mechanisms underlying vocal tics remain unexplored because of no established animal model representing the condition. We report unilateral disinhibition of the nucleus accumbens (NAc) generates vocal tics in monkeys. Whole-brain PET imaging identified prominent, bilateral limbic corticosubcortical activation. Local field potentials (LFPs) usually developed abnormal spikes in the NAc and the anterior cingulate cortex (ACC). The behavioral manifestation could occur without obvious LFP spikes, however, when phase-phase coupling of alpha oscillations were accentuated between the NAc, ACC, and the primary motor cortex. These findings contrasted with myoclonic motor tics induced by disinhibition of the dorsolateral putamen, where PET activity was confined to the ipsilateral sensorimotor system and LFP spikes always preceded motor tics. We propose that vocal tics emerge as a consequence of dysrhythmic alpha coupling between critical nodes in the limbic and motor networks. | |||||
| 書誌情報 |
Neuron 巻 89, 号 2, p. 300-307, 発行日 2016-01 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0896-6273 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 26796690 | |||||
