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PET Quantification of Tau Pathology in Human Brain with 11C-PBB3
https://repo.qst.go.jp/records/47477
https://repo.qst.go.jp/records/474778cc90302-08ed-49d5-9c6d-582c80b80949
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-08-22 | |||||
| タイトル | ||||||
| タイトル | PET Quantification of Tau Pathology in Human Brain with 11C-PBB3 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kimura, Yasuyuki
× Kimura, Yasuyuki× Ichise, Masanori× Ito, Hiroshi× Shimada, Hitoshi× Ikoma, Yoko× Seki, Chie× Takano, Harumasa× Kitamura, Soichiro× Shinotoh, Hitoshi× Kawamura, Kazunori× Zhang, Ming-Rong× Sahara, Naruhiko× Suhara, Tetsuya× Higuchi, Makoto× 木村 泰之× 市瀬 正則× 伊藤 浩× 島田 斉× 生駒 洋子× 関 千江× 高野 晴成× 北村 聡一郎× 篠遠 仁× 河村 和紀× 張 明栄× 佐原 成彦× 須原 哲也× 樋口 真人 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Tau accumulation in the brain is a pathological hallmark of Alzheimer’s disease (AD) and other tauopathies. Quantitative visualization of tau pathology in humans can be a powerful method as a diagnostic aid and for monitoring potential therapeutic interventions. We established methods of PET quantification of tau pathology with 11C-PBB3 considering its radiometabolite entering the brain. Methods: Seven AD and seven healthy subjects underwent dynamic 11C-PBB3 PET scanning. Arterial blood was sampled to obtain the parent and metabolite input functions. Quantification of 11C-PBB3 binding was performed using dual-input models that take the brain metabolite activity into consideration, traditional single-input models without such considerations, and the reference tissue model (MRTMO) and standardized uptake value ratio (SUVR). The cerebellar cortex was used as the reference tissue for all methods. Results: The dual-input graphical models estimated binding parameter (BPND∗ ) stably (~0.36 in high binding regions). The MRTMO BPND∗ matched the corresponding BPND∗ by the dual-input graphical model (r2 = 1.00). SUVR-1 correlated very well with MRTMO BPND∗ (r2 > 0.97). However, BPND by the single-input models did not correlate with BPND∗ by the dual-input graphical model (r2 = 0.04). Conclusions: The dual-input graphical model BPND∗ is consistent with the reference tissue BPND∗ and SUVR-1, suggesting that these parameters can accurately quantify binding of 11C-PBB3 despite the entry of its radiometabolites into the brain. KEY WORDS: PET quantification, tau, 11C-PBB3, Alzheimer’s disease |
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| 書誌情報 |
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 巻 56, 号 9, p. 1359-1365, 発行日 2015-07 |
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| 出版者 | ||||||
| 出版者 | Society of Nuclear Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0161-5505 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 26182966 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.2967/jnumed.115.160127 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://jnm.snmjournals.org/content/early/2015/07/15/jnumed.115.160127.abstract | |||||
| 関連名称 | http://jnm.snmjournals.org/content/early/2015/07/15/jnumed.115.160127.abstract | |||||
