{"created":"2023-05-15T14:36:50.960407+00:00","id":47477,"links":{},"metadata":{"_buckets":{"deposit":"d71b3c11-324e-4d13-8558-bbbce0b35275"},"_deposit":{"created_by":1,"id":"47477","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47477"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047477","sets":["1"]},"author_link":["475663","475676","475684","475679","475682","475658","475673","475678","475672","475669","475659","475660","475664","475670","475666","475681","475683","475677","475674","475661","475671","475662","475668","475675","475680","475657","475665","475667"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"1365","bibliographicPageStart":"1359","bibliographicVolumeNumber":"56","bibliographic_titles":[{"bibliographic_title":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Tau accumulation in the brain is a pathological hallmark of Alzheimer’s disease (AD) and other tauopathies. Quantitative visualization of tau pathology in humans can be a powerful method as a diagnostic aid and for monitoring potential therapeutic interventions. We established methods of PET quantification of tau pathology with 11C-PBB3 considering its radiometabolite entering the brain. Methods: Seven AD and seven healthy subjects underwent dynamic 11C-PBB3 PET scanning. Arterial blood was sampled to obtain the parent and metabolite input functions. Quantification of 11C-PBB3 binding was performed using dual-input models that take the brain metabolite activity into consideration, traditional single-input models without such considerations, and the reference tissue model (MRTMO) and standardized uptake value ratio\n(SUVR). The cerebellar cortex was used as the reference tissue for all methods.\nResults: The dual-input graphical models estimated binding parameter (BPND∗ ) stably (~0.36 in high binding regions). The MRTMO BPND∗ matched the corresponding BPND∗ by the dual-input graphical model (r2 = 1.00). SUVR-1 correlated very well with MRTMO BPND∗ (r2 > 0.97). However, BPND by the single-input models did not correlate with BPND∗ by the dual-input graphical model (r2 = 0.04). Conclusions: The dual-input graphical model BPND∗ is consistent with the reference tissue BPND∗ and SUVR-1, suggesting that these parameters can accurately quantify binding of 11C-PBB3 despite the entry of its radiometabolites into the brain.\nKEY WORDS: PET quantification, tau, 11C-PBB3, Alzheimer’s disease","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Society of Nuclear Medicine"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"26182966","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2967/jnumed.115.160127","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://jnm.snmjournals.org/content/early/2015/07/15/jnumed.115.160127.abstract"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://jnm.snmjournals.org/content/early/2015/07/15/jnumed.115.160127.abstract","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0161-5505","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kimura, Yasuyuki"}],"nameIdentifiers":[{"nameIdentifier":"475657","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichise, Masanori"}],"nameIdentifiers":[{"nameIdentifier":"475658","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"475659","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"475660","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikoma, Yoko"}],"nameIdentifiers":[{"nameIdentifier":"475661","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seki, Chie"}],"nameIdentifiers":[{"nameIdentifier":"475662","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takano, Harumasa"}],"nameIdentifiers":[{"nameIdentifier":"475663","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitamura, Soichiro"}],"nameIdentifiers":[{"nameIdentifier":"475664","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinotoh, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"475665","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawamura, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"475666","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"475667","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sahara, Naruhiko"}],"nameIdentifiers":[{"nameIdentifier":"475668","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"475669","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"475670","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 泰之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475671","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"市瀬 正則","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475672","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475673","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475674","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生駒 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475675","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関 千江","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475676","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475677","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北村 聡一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475678","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475679","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475680","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475681","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐原 成彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475682","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475683","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475684","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"PET Quantification of Tau Pathology in Human Brain with 11C-PBB3","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PET Quantification of Tau Pathology in Human Brain with 11C-PBB3"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-08-22"},"publish_date":"2016-08-22","publish_status":"0","recid":"47477","relation_version_is_last":true,"title":["PET Quantification of Tau Pathology in Human Brain with 11C-PBB3"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:39:21.790208+00:00"}