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Dementia with Lewy bodies can be well-differentiated from Alzheimer’s disease by measurement of brain acetylcholinesterase activity - A [11C]MP4A PET study -
https://repo.qst.go.jp/records/47476
https://repo.qst.go.jp/records/474768d424832-72ad-4956-8780-cb2d5e40f4bb
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-08-22 | |||||
| タイトル | ||||||
| タイトル | Dementia with Lewy bodies can be well-differentiated from Alzheimer’s disease by measurement of brain acetylcholinesterase activity - A [11C]MP4A PET study - | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shimada, Hitoshi
× Shimada, Hitoshi× Shinotoh, Hitoshi× Ota, Tsuneyoshi× Sato, Koichi× Yamada, Makiko× Fukushi, Kiyoshi× Irie, Toshiaki× Zhang, Ming-Rong× Higuchi, Makoto× Kuwabara, Satoshi× Suhara, Tetsuya× Hirano, Shigeki× al, et× 島田 斉× 篠遠 仁× 黄田 常嘉× 佐藤 康一× 山田 真希子× 福士 清× 入江 俊章× 張 明栄× 樋口 真人× 須原 哲也× 平野 成樹 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: To investigate the diagnostic performance of brain acetylcholinesterase (AChE) activity measurement using N-[11C]-methyl-4-piperidyl acetate (MP4A) and PET in patients with dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD). Methods: Participants were 14 DLB patients, 25 AD patients, and 18 age-matched healthy controls (HC). All subjects underwent PET scans and MP4A to measure regional brain AChE activity. We performed anatomical standardization of each brain image, and k3 values, an index of AChE activity, in each voxel were estimated by nonlinear least squares analysis. Volumes of interest (VOIs) were identified on parametric k3 images in frontal, temporal, parietal and occipital cortices, and in anterior and posterior cingulate gyri (ACG, PCG). In each VOI, the differential diagnostic performance between AD and DLB of k3 values was assessed by area under the curve (AUC) of the receiver-operating characteristic. Voxel-based statistical analyses were also performed. Results: Mean cortical AChE activities in AD patients (-8.2% compared with normal mean) and DLB patients (-27.8%) were lower than HCs (p < 0.05, p < 0.001, respectively). There was a significant difference in mean cortical AChE activities between AD and DLB patients (p < 0.001). All regional brain AChE activities of defined VOIs except ACG were able to well discriminate DLB from AD, and notably performance was the most significant in PCG (AUC = 0.989, 95% CI: 0.965-1.000). Conclusions: Brain cholinergic deficit is consistently prominent in DLB compared with AD. PET measurement of brain AChE activity may be useful for the differential diagnosis between DLB and AD. |
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| 書誌情報 |
International Journal of Geriatric Psychiatry 巻 30, 号 11, p. 1105-1113, 発行日 2015-08 |
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| 出版者 | ||||||
| 出版者 | John Wiley | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0885-6230 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 26280153 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/gps.4338 | |||||
