@article{oai:repo.qst.go.jp:00047476,
 author = {Shimada, Hitoshi and Shinotoh, Hitoshi and Ota, Tsuneyoshi and Sato, Koichi and Yamada, Makiko and Fukushi, Kiyoshi and Irie, Toshiaki and Zhang, Ming-Rong and Higuchi, Makoto and Kuwabara, Satoshi and Suhara, Tetsuya and Hirano, Shigeki and al, et and 島田 斉 and 篠遠 仁 and 黄田 常嘉 and 佐藤 康一 and 山田 真希子 and 福士 清 and 入江 俊章 and 張 明栄 and 樋口 真人 and 須原 哲也 and 平野 成樹},
 issue = {11},
 journal = {International Journal of Geriatric Psychiatry},
 month = {Aug},
 note = {Objective: To investigate the diagnostic performance of brain acetylcholinesterase (AChE)
activity measurement using N-[11C]-methyl-4-piperidyl acetate (MP4A) and PET in patients
with dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD).
Methods: Participants were 14 DLB patients, 25 AD patients, and 18 age-matched healthy
controls (HC). All subjects underwent PET scans and MP4A to measure regional brain AChE
activity. We performed anatomical standardization of each brain image, and k3 values, an
index of AChE activity, in each voxel were estimated by nonlinear least squares analysis.
Volumes of interest (VOIs) were identified on parametric k3 images in frontal, temporal,
parietal and occipital cortices, and in anterior and posterior cingulate gyri (ACG, PCG). In
each VOI, the differential diagnostic performance between AD and DLB of k3 values was
assessed by area under the curve (AUC) of the receiver-operating characteristic. Voxel-based
statistical analyses were also performed.
Results: Mean cortical AChE activities in AD patients (-8.2% compared with normal mean)
and DLB patients (-27.8%) were lower than HCs (p < 0.05, p < 0.001, respectively). There
was a significant difference in mean cortical AChE activities between AD and DLB patients
(p < 0.001). All regional brain AChE activities of defined VOIs except ACG were able to well
discriminate DLB from AD, and notably performance was the most significant in PCG (AUC
= 0.989, 95% CI: 0.965-1.000).
Conclusions: Brain cholinergic deficit is consistently prominent in DLB compared with AD.
PET measurement of brain AChE activity may be useful for the differential diagnosis between
DLB and AD.},
 pages = {1105--1113},
 title = {Dementia with Lewy bodies can be well-differentiated from Alzheimer’s disease by measurement of brain acetylcholinesterase activity - A [11C]MP4A PET study -},
 volume = {30},
 year = {2015}
}