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Density of Hydroxyl Radicals Generated in an Aqueous Solution by Irradiating Carbon-Ion Beam
https://repo.qst.go.jp/records/47473
https://repo.qst.go.jp/records/47473a9849c31-b48c-4742-97b5-bf644fae2cd4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Matsumoto.K.2015.Chem.Pharm.Bull.63.195-199.pdf (566.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2015-01-05 | |||||
| タイトル | ||||||
| タイトル | Density of Hydroxyl Radicals Generated in an Aqueous Solution by Irradiating Carbon-Ion Beam | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ken-ichiro, Matsumoto
× Ken-ichiro, Matsumoto× Ueno, Megumi× Nakanishi, Ikuo× Anzai, Kazunori× Kenichiro, Matsumoto× Megumi, Ueno× Ikuo, Nakanishi× Kazunori, Anzai |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The density of hydroxyl radicals (•OH) produced in aqueous samples by exposure to X-ray or carbon-ion beams was investigated. The generation of •OH was detected by the electron paramagnetic resonance (EPR) spin-trapping technique using 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) as the spin-trapping agent. When the concentration of DMPO is in excess of the generated •OH, the production of DMPO-OH (spin-trapped •OH) should be saturated. Reaction mixtures containing several concentrations (0.5–1685 mM) of DMPO were then irradiated by a 32 Gy 290 MeV carbon-ion beam (C290-beam) or X-ray. C290-beam irradiation was performed at the Heavy-Ion Medical Accelerator in Chiba (HIMAC, National Institute of Radiological Sciences, Chiba, Japan), applying different linear energy transfers (LET) (20 to 169 keV/μm). The amount of DMPO-OH in the irradiated samples was detected by EPR spectroscopy. The generation of DMPO-OH increased with the concentration of initial DMPO, displayed a shoulder around 3.3 mM DMPO, and reached a plateau. This plateau suggests that the generated •OH were completely trapped and able to be detected. A steep linear increase in DMPO-OH measured in solutions with higher DMPO concentrations suggested very dense •OH generation (> 1.7 M). Generation of •OH is expected to be localized on the track of the radiation beam, because the maximum concentration of measured DMPO-OH concentration was 40 μM. These results suggested that both sparse (≈ 3.3 mM) and dense (> 1.7 M) •OH generation occurred in the irradiated samples. The percentage of dense •OH generation increased with increasing LET. Different types of dense •OH generation may be expected for X-ray and C290-beams. | |||||
| 書誌情報 |
Chemical & Pharmaceutical Bulletin 巻 63, 号 3, p. 195-199, 発行日 2015-03 |
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| 出版者 | ||||||
| 出版者 | Nihon Yakugakkai | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0009-2363 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 25757490 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1248/cpb.c14-00736 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1248/cpb.c14-00736 | |||||
