{"created":"2023-05-15T14:36:50.786339+00:00","id":47473,"links":{},"metadata":{"_buckets":{"deposit":"e5eb29d7-ae5e-4c31-9263-df31a8997a54"},"_deposit":{"created_by":1,"id":"47473","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47473"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047473","sets":["1"]},"author_link":["1024749","1024755","1024752","1024750","1024756","1024754","1024751","1024753"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"199","bibliographicPageStart":"195","bibliographicVolumeNumber":"63","bibliographic_titles":[{"bibliographic_title":"Chemical & Pharmaceutical Bulletin"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The density of hydroxyl radicals (•OH) produced in aqueous samples by exposure to X-ray or carbon-ion beams was investigated. The generation of •OH was detected by the electron paramagnetic resonance (EPR) spin-trapping technique using 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) as the spin-trapping agent. When the concentration of DMPO is in excess of the generated •OH, the production of DMPO-OH (spin-trapped •OH) should be saturated. Reaction mixtures containing several concentrations (0.5–1685 mM) of DMPO were then irradiated by a 32 Gy 290 MeV carbon-ion beam (C290-beam) or X-ray. C290-beam irradiation was performed at the Heavy-Ion Medical Accelerator in Chiba (HIMAC, National Institute of Radiological Sciences, Chiba, Japan), applying different linear energy transfers (LET) (20 to 169 keV/μm). The amount of DMPO-OH in the irradiated samples was detected by EPR spectroscopy. The generation of DMPO-OH increased with the concentration of initial DMPO, displayed a shoulder around 3.3 mM DMPO, and reached a plateau. This plateau suggests that the generated •OH were completely trapped and able to be detected. A steep linear increase in DMPO-OH measured in solutions with higher DMPO concentrations suggested very dense •OH generation (> 1.7 M). Generation of •OH is expected to be localized on the track of the radiation beam, because the maximum concentration of measured DMPO-OH concentration was 40 μM. These results suggested that both sparse (≈ 3.3 mM) and dense (> 1.7 M) •OH generation occurred in the irradiated samples. The percentage of dense •OH generation increased with increasing LET. Different types of dense •OH generation may be expected for X-ray and C290-beams.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nihon Yakugakkai"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"25757490","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/cpb.c14-00736","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1248/cpb.c14-00736","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0009-2363","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ken-ichiro, Matsumoto"}],"nameIdentifiers":[{"nameIdentifier":"1024749","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ueno, Megumi"}],"nameIdentifiers":[{"nameIdentifier":"1024750","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakanishi, Ikuo"}],"nameIdentifiers":[{"nameIdentifier":"1024751","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Anzai, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"1024752","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kenichiro, Matsumoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1024753","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Megumi, Ueno","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1024754","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikuo, Nakanishi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1024755","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazunori, Anzai","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1024756","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-28"}],"displaytype":"detail","filename":"96866be7aa1308a822a77bd893f8f9cf.pdf","filesize":[{"value":"566.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Matsumoto.K.2015.Chem.Pharm.Bull.63.195-199.pdf","url":"https://repo.qst.go.jp/record/47473/files/96866be7aa1308a822a77bd893f8f9cf.pdf"},"version_id":"396da504-2b87-45cb-be2d-db7e01f09167"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Density of Hydroxyl Radicals Generated in an Aqueous Solution by Irradiating Carbon-Ion Beam","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Density of Hydroxyl Radicals Generated in an Aqueous Solution by Irradiating Carbon-Ion Beam"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-01-05"},"publish_date":"2015-01-05","publish_status":"0","recid":"47473","relation_version_is_last":true,"title":["Density of Hydroxyl Radicals Generated in an Aqueous Solution by Irradiating Carbon-Ion Beam"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:05:04.978233+00:00"}