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Lymph node mapping using quantum dot-labeled polymersomes
https://repo.qst.go.jp/records/47458
https://repo.qst.go.jp/records/4745879dddda4-3a5d-4e51-9ffe-c50ab30ab0d5
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-08-10 | |||||
| タイトル | ||||||
| タイトル | Lymph node mapping using quantum dot-labeled polymersomes | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Rumiana, Bakalova
× Rumiana, Bakalova× Zhelov, Zhivko× Nikolova, Billiana× Murayama, Shuhei× Lazarova, Desislava× Tsoneva, Idana× Aoki, Ichio× Saga, Tsuneo× バカロバ ルミアナ× 村山 周平× 青木 伊知男× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The present study was designed to investigate whether poly-ion complex hollow vesicles (polymersomes), based on chemically-modified chitosan, are appropriate for lymph node mapping in the context of their application in the development of theranostic nanosized drug delivery systems (nano-DDS). The experiments were performed on Balb/c nude mice (colon cancer-grafted). The mice were subjected to anesthesia and quantum dot (QD705)-labeled polymersomes (d~120 nm) were injected intravenously via the tail vein. The optical imaging was carried out on Maestro EX Imaging System (excitation filter: 435–480 nm; emission filter: 700 nm). A strong fluorescent signal, correspondingto QD705 fluorescence, was detected in thelymph nodes, as well as in the tumor. A very weak fluorescent signal was found in the liver area. The half-life of QD705-labelled polymersomeswas 6 ± 2 hours in the bloodstream and 11 ± 3 hours in the lymph nodes. The data suggest that polymersomes are very promising carriers for lymph node mapping using QD as a contrast agent. They are useful matrix for development of nano-formulations with theranostic capabilities. | |||||
| 書誌情報 |
General Physiology and Biophysics 巻 34, 号 4, p. 393-398, 発行日 2015-10 |
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| 出版者 | ||||||
| 出版者 | AEPress | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0231-5882 | |||||
