{"created":"2023-05-15T14:36:50.121994+00:00","id":47458,"links":{},"metadata":{"_buckets":{"deposit":"c9c515f0-fbba-4ef4-b7ce-3cafb4de016b"},"_deposit":{"created_by":1,"id":"47458","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47458"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047458","sets":["1"]},"author_link":["475422","475418","475426","475419","475428","475420","475427","475423","475424","475425","475421","475417"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"398","bibliographicPageStart":"393","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"General Physiology and Biophysics"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The present study was designed to investigate whether poly-ion complex hollow vesicles (polymersomes), based on chemically-modified chitosan, are appropriate for lymph node mapping in the context of their application in the development of theranostic nanosized drug delivery systems (nano-DDS). The experiments were performed on Balb/c nude mice (colon cancer-grafted). The mice were subjected to anesthesia and quantum dot (QD705)-labeled polymersomes (d~120 nm) were injected intravenously via the tail vein. The optical imaging was carried out on Maestro EX Imaging System (excitation filter: 435–480 nm; emission filter: 700 nm). A strong fluorescent signal, correspondingto QD705 fluorescence, was detected in thelymph nodes, as well as in the tumor. A very weak fluorescent signal was found in the liver area. The half-life of QD705-labelled polymersomeswas 6 ± 2 hours in the bloodstream and 11 ± 3 hours in the lymph nodes. The data suggest that polymersomes are very promising carriers for lymph node mapping using QD as a contrast agent. They are useful matrix for development of nano-formulations with theranostic capabilities.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"AEPress"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0231-5882","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Rumiana, Bakalova"}],"nameIdentifiers":[{"nameIdentifier":"475417","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhelov, Zhivko"}],"nameIdentifiers":[{"nameIdentifier":"475418","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nikolova, Billiana"}],"nameIdentifiers":[{"nameIdentifier":"475419","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murayama, Shuhei"}],"nameIdentifiers":[{"nameIdentifier":"475420","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lazarova, Desislava"}],"nameIdentifiers":[{"nameIdentifier":"475421","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsoneva, Idana"}],"nameIdentifiers":[{"nameIdentifier":"475422","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"475423","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"475424","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"バカロバ ルミアナ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475425","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村山 周平","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475426","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475427","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475428","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Lymph node mapping using quantum dot-labeled polymersomes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Lymph node mapping using quantum dot-labeled polymersomes"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-08-10"},"publish_date":"2016-08-10","publish_status":"0","recid":"47458","relation_version_is_last":true,"title":["Lymph node mapping using quantum dot-labeled polymersomes"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:39:36.402974+00:00"}