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Genetic Analysis of T Cell Lymphomas in Carbon Ion-Irradiated Mice Reveals Frequent Interstitial Chromosome Deletions: Implications for Second Cancer Induction in Normal Tissues During Carbon Ion Radiotherapy
https://repo.qst.go.jp/records/47442
https://repo.qst.go.jp/records/47442c2694a75-1bfb-425a-ac33-f0912166e14d
| 名前 / ファイル | ライセンス | アクション |
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Blyth_2015_CarbonTL.pdf (2.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2016-07-21 | |||||
| タイトル | ||||||
| タイトル | Genetic Analysis of T Cell Lymphomas in Carbon Ion-Irradiated Mice Reveals Frequent Interstitial Chromosome Deletions: Implications for Second Cancer Induction in Normal Tissues During Carbon Ion Radiotherapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ｂｌｙｔｈ, Ｂｅｎｊａｍｉｎ
× Ｂｌｙｔｈ, Ｂｅｎｊａｍｉｎ× 柿沼, 志津子× 砂押, 正章× 甘崎, 佳子× 坂入, しのぶ× 小川, 佳那依× 白神, 綾奈× 尚, 奕× 鶴岡, 千鶴× 西村, まゆみ× 島田, 義也× Ｂｌｙｔｈ Ｂｅｎｊａｍｉｎ× 柿沼 志津子× 砂押 正章× 甘崎 佳子× 坂入 しのぶ× 小川 佳那依× 白神 綾奈× 尚 奕× 鶴岡 千鶴× 西村 まゆみ× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Monitoring mice exposed to carbon ion radiotherapy provides an indirect method to evaluate the potential for second cancer induction in normal tissues outside the radiotherapy target volume, since such estimates are not yet possible from historical patient data. Here, male and female B6C3F1 mice were given single or fractionated whole-body exposure(s) to a monoenergetic carbon ion radiotherapy beam at the Heavy Ion Medical Accelerator in Chiba, Japan, matching the radiation quality delivered to the normal tissue ahead of the tumour volume (average linear energy transfer = 13 keV.μm-1) during patient radiotherapy protocols. The mice were monitored for the remainder of their lifespan, and a large number of T cell lymphomas that arose in these mice were analysed alongside those arising following an equivalent dose of 137Cs gamma ray-irradiation. Using genome-wide DNA copy number analysis to identify genomic loci involved in radiation-induced lymphomagenesis and subsequent detailed analysis of Notch1, Ikzf1, Pten, Trp53 and Bcl11b genes, we compared the genetic profile of the carbon ion- and gamma ray-induced tumours. The canonical set of genes previously associated with radiationinduced T cell lymphoma was identified in both radiation groups. While the pattern of disruption of the various pathways was somewhat different between the radiation types, most notably Pten mutation frequency and loss of heterozygosity flanking Bcl11b, the most striking finding was the observation of large interstitial deletions at various sites across the genome in carbon ion-induced tumours, which were only seen infrequently in the gamma ray-induced tumours analysed. If such large interstitial chromosomal deletions are a characteristic lesion of carbon ion irradiation, even when using the low linear energy transfer radiation to which normal tissues are exposed in radiotherapy patients, understanding the dose-response and tissue specificity of such DNA damage could prove key to assessing second cancer risk in carbon ion radiotherapy patients. |
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| 書誌情報 |
PLOS ONE 巻 10, 号 6, p. e0130666-1-e0130666-24, 発行日 2015-06 |
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| 出版者 | ||||||
| 出版者 | Public Library of Science | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1932-6203 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1371/journal.pone.0130666.t001 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130666 | |||||
| 関連名称 | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130666 | |||||
