{"created":"2023-05-15T14:36:49.419807+00:00","id":47442,"links":{},"metadata":{"_buckets":{"deposit":"e705a2ea-070b-4cb9-91d3-2fa2bfee0496"},"_deposit":{"created_by":1,"id":"47442","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47442"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047442","sets":["1"]},"author_link":["475230","475251","475231","475250","475240","475247","475244","475249","475239","475232","475246","475233","475235","475242","475241","475248","475236","475237","475234","475245","475238","475243"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"e0130666-24","bibliographicPageStart":"e0130666-1","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"PLOS ONE"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Monitoring mice exposed to carbon ion radiotherapy provides an indirect method to evaluate the potential for second cancer induction in\nnormal tissues outside the radiotherapy target volume, since such estimates are not yet possible from historical patient data. Here, male\nand female B6C3F1 mice were given single or fractionated whole-body exposure(s) to a monoenergetic carbon ion radiotherapy beam at\nthe Heavy Ion Medical Accelerator in Chiba, Japan, matching the radiation quality delivered to the normal tissue ahead of the tumour\nvolume (average linear energy transfer = 13 keV.μm-1) during patient radiotherapy protocols. The mice were monitored for the remainder\nof their lifespan, and a large number of T cell lymphomas that arose in these mice were analysed alongside those arising following an\nequivalent dose of 137Cs gamma ray-irradiation. Using genome-wide DNA copy number analysis to identify genomic loci involved in\nradiation-induced lymphomagenesis and subsequent detailed analysis of Notch1, Ikzf1, Pten, Trp53 and Bcl11b genes, we compared the\ngenetic profile of the carbon ion- and gamma ray-induced tumours. The canonical set of genes previously associated with radiationinduced\nT cell lymphoma was identified in both radiation groups. While the pattern of disruption of the various pathways was somewhat\ndifferent between the radiation types, most notably Pten mutation frequency and loss of heterozygosity flanking Bcl11b, the most striking\nfinding was the observation of large interstitial deletions at various sites across the genome in carbon ion-induced tumours, which were\nonly seen infrequently in the gamma ray-induced tumours analysed. If such large interstitial chromosomal deletions are a characteristic\nlesion of carbon ion irradiation, even when using the low linear energy transfer radiation to which normal tissues are exposed in\nradiotherapy patients, understanding the dose-response and tissue specificity of such DNA damage could prove key to assessing second\ncancer risk in carbon ion radiotherapy patients.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pone.0130666.t001","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130666"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130666","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ｂｌｙｔｈ, Ｂｅｎｊａｍｉｎ"}],"nameIdentifiers":[{"nameIdentifier":"475230","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼, 志津子"}],"nameIdentifiers":[{"nameIdentifier":"475231","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"砂押, 正章"}],"nameIdentifiers":[{"nameIdentifier":"475232","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"甘崎, 佳子"}],"nameIdentifiers":[{"nameIdentifier":"475233","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂入, しのぶ"}],"nameIdentifiers":[{"nameIdentifier":"475234","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川, 佳那依"}],"nameIdentifiers":[{"nameIdentifier":"475235","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"白神, 綾奈"}],"nameIdentifiers":[{"nameIdentifier":"475236","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"尚, 奕"}],"nameIdentifiers":[{"nameIdentifier":"475237","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鶴岡, 千鶴"}],"nameIdentifiers":[{"nameIdentifier":"475238","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村, まゆみ"}],"nameIdentifiers":[{"nameIdentifier":"475239","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 義也"}],"nameIdentifiers":[{"nameIdentifier":"475240","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｂｌｙｔｈ Ｂｅｎｊａｍｉｎ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475241","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼 志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475242","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"砂押 正章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475243","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"甘崎 佳子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475244","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂入 しのぶ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475245","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川 佳那依","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475246","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"白神 綾奈","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475247","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"尚 奕","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475248","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鶴岡 千鶴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475249","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475250","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475251","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-02-14"}],"displaytype":"detail","filename":"1747ea53986dc113b6ff7fbff2b997a9.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Blyth_2015_CarbonTL.pdf","url":"https://repo.qst.go.jp/record/47442/files/1747ea53986dc113b6ff7fbff2b997a9.pdf"},"version_id":"411ad01c-275d-4a66-8c66-6350f8e12a6c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Genetic Analysis of T Cell Lymphomas in Carbon Ion-Irradiated Mice Reveals Frequent Interstitial Chromosome Deletions: Implications for Second Cancer Induction in Normal Tissues During Carbon Ion Radiotherapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Genetic Analysis of T Cell Lymphomas in Carbon Ion-Irradiated Mice Reveals Frequent Interstitial Chromosome Deletions: Implications for Second Cancer Induction in Normal Tissues During Carbon Ion Radiotherapy"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-07-21"},"publish_date":"2016-07-21","publish_status":"0","recid":"47442","relation_version_is_last":true,"title":["Genetic Analysis of T Cell Lymphomas in Carbon Ion-Irradiated Mice Reveals Frequent Interstitial Chromosome Deletions: Implications for Second Cancer Induction in Normal Tissues During Carbon Ion Radiotherapy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:39:47.656830+00:00"}