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In vivo imaging of blood–brain barrier permeability using positron emission tomography with 2-amino-[3-11C]isobutyric acid
https://repo.qst.go.jp/records/47363
https://repo.qst.go.jp/records/47363da421800-d787-40e3-a9ef-7e97a912e05d
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-01-18 | |||||
| タイトル | ||||||
| タイトル | In vivo imaging of blood–brain barrier permeability using positron emission tomography with 2-amino-[3-11C]isobutyric acid | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Okada, Maki
× Okada, Maki× Kikuchi, Tatsuya× Okamura, Toshimitsu× Ikoma, Yoko× Tsuji, Atsushi× Wakizaka, Hidekatsu× Aoki, Ichio× Zhang, Ming-Rong× Kato, Koichi× Kamakura, Tomoo× 岡田 真希× 菊池 達矢× 岡村 敏充× 生駒 洋子× 辻 厚至× 脇坂 秀克× 青木 伊知男× 張 明栄× 加藤 孝一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The blood–brain barrier (BBB) limits the entry of some therapeutics into the brain, resulting in reduced efficacy. BBB-opening techniques have been developed to enhance the entry into the brain. However, a non-invasive, highly sensitive and quantitative method for evaluating the changes in BBB permeability induced by such techniques is needed to optimise treatment protocols. We evaluated 2-amino-[3-11C]isobutyric acid ([3-11C]AIB) as a positron emission tomography (PET) probe for quantifying BBB permeability in model rats. BBB opening was induced by a lipopolysaccharide injection or focused ultrasound (FUS) sonication. [3-11C]AIB distribution in the brain was evaluated by autoradiography and PET and compared with that of Evans blue (EB), a traditional BBB permeability marker. Kinetics of [3-11C]AIB was compared with that of gadolinium–diethylenetriamine pentaacetic acid (Gd-DTPA)-enhanced magnetic resonance imaging. The unidirectional blood–brain transfer constant (Ki) of [3-11C]AIB was estimated using Patlak plot. [3-11C]AIB uptake in the lesion area was significantly higher than that in the control area, and radioactivity co-localised with EB in both models. [3-11C]AIB uptake in the FUS-sonicated region decreased over time after sonication. The ratio of [3-11C]AIB accumulation in the FUS-treated to the contralateral side increased during the experiment time, whereas that of Gd-DTPA intensity reached a maximum at 10 min post-injection and decreased thereafter. The [3-11C]AIB Ki values were significantly higher in the lesion area than the control area. [3-11C]AIB PET is a promising, highly sensitive and quantitative imaging method for assessing BBB permeability. |
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| 書誌情報 |
Nuclear Medicine Communications 巻 36, 号 12, p. 1239-1248, 発行日 2015-12 |
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| 出版者 | ||||||
| 出版者 | Lippincott Williams & Wilkins | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 26397998 | |||||
