{"created":"2023-05-15T14:36:45.770475+00:00","id":47363,"links":{},"metadata":{"_buckets":{"deposit":"c72a5b89-5f2d-4447-8907-e46c8beaeceb"},"_deposit":{"created_by":1,"id":"47363","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47363"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047363","sets":["1"]},"author_link":["474070","474074","474084","474079","474080","474085","474081","474083","474082","474078","474086","474071","474077","474076","474087","474073","474069","474075","474072"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1248","bibliographicPageStart":"1239","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"Nuclear Medicine Communications"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The blood–brain barrier (BBB) limits the entry of some therapeutics into the brain, resulting in reduced efficacy. BBB-opening techniques have been developed to enhance the entry into the brain. However, a non-invasive, highly sensitive and quantitative method for evaluating the changes in BBB permeability induced by such techniques is needed to optimise treatment protocols. We evaluated 2-amino-[3-11C]isobutyric acid ([3-11C]AIB) as a positron emission tomography (PET) probe for quantifying BBB permeability in model rats.\nBBB opening was induced by a lipopolysaccharide injection or focused ultrasound (FUS) sonication. [3-11C]AIB distribution in the brain was evaluated by autoradiography and PET and compared with that of Evans blue (EB), a traditional BBB permeability marker. Kinetics of [3-11C]AIB was compared with that of gadolinium–diethylenetriamine pentaacetic acid (Gd-DTPA)-enhanced magnetic resonance imaging. The unidirectional blood–brain transfer constant (Ki) of [3-11C]AIB was estimated using Patlak plot.\n[3-11C]AIB uptake in the lesion area was significantly higher than that in the control area, and radioactivity co-localised with EB in both models. [3-11C]AIB uptake in the FUS-sonicated region decreased over time after sonication. The ratio of [3-11C]AIB accumulation in the FUS-treated to the contralateral side increased during the experiment time, whereas that of Gd-DTPA intensity reached a maximum at 10 min post-injection and decreased thereafter. The [3-11C]AIB Ki values were significantly higher in the lesion area than the control area.\n[3-11C]AIB PET is a promising, highly sensitive and quantitative imaging method for assessing BBB permeability.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Lippincott Williams & Wilkins"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"26397998","subitem_relation_type_select":"PMID"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Okada, Maki"}],"nameIdentifiers":[{"nameIdentifier":"474069","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kikuchi, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"474070","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okamura, Toshimitsu"}],"nameIdentifiers":[{"nameIdentifier":"474071","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikoma, Yoko"}],"nameIdentifiers":[{"nameIdentifier":"474072","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"474073","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakizaka, Hidekatsu"}],"nameIdentifiers":[{"nameIdentifier":"474074","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"474075","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"474076","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"474077","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamakura, Tomoo"}],"nameIdentifiers":[{"nameIdentifier":"474078","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡田 真希","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474079","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菊池 達矢","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474080","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡村 敏充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474081","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生駒 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474082","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 厚至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474083","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474084","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474085","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474086","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 孝一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474087","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"In vivo imaging of blood–brain barrier permeability using positron emission tomography with 2-amino-[3-11C]isobutyric acid","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"In vivo imaging of blood–brain barrier permeability using positron emission tomography with 2-amino-[3-11C]isobutyric acid"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-01-18"},"publish_date":"2016-01-18","publish_status":"0","recid":"47363","relation_version_is_last":true,"title":["In vivo imaging of blood–brain barrier permeability using positron emission tomography with 2-amino-[3-11C]isobutyric acid"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:40:44.569000+00:00"}