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Hemodynamic changes during neural deactivation in awake mice: A measurement by laser-Doppler flowmetry in crossed cerebellar diaschisis
https://repo.qst.go.jp/records/47323
https://repo.qst.go.jp/records/47323e49c5e53-b5e1-49a0-ac24-d6a5cf1fe313
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-11-13 | |||||
タイトル | ||||||
タイトル | Hemodynamic changes during neural deactivation in awake mice: A measurement by laser-Doppler flowmetry in crossed cerebellar diaschisis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Takuwa, Hiroyuki
× Takuwa, Hiroyuki× Tajima, Yousuke× Kokuryo, Daisuke× Matsuura, Tetsuya× Kawaguchi, Hiroshi× Masamoto, Kazuto× Taniguchi, Jyunko× Ikoma, Yoko× Seki, Chie× Aoki, Ichio× Tomita, Yutaka× Suzuki, Norihiro× Kanno, Iwao× Ito, Hiroshi× 田桑 弘之× 田島 洋佑× 國領 大介× 松浦 哲也× 川口 拓之× 正本 和人× 谷口 順子× 生駒 洋子× 関 千江× 青木 伊知男× 冨田 裕× 菅野 巖× 伊藤 浩 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Crossed cerebellar diaschisis (CCD) caused by contralateral supratentorial lesions can be considered a condition of neural deactivation, and hemodynamic changes in CCD were investigated with positron emission tomography (PET) in humans. In the present study, to investigate the effects of neural deactivation on hemodynamics, we developed a new mouse model of CCD, which was caused by middle cerebral artery occlusion (MCAO), and measured changes in cerebellar blood flow (CbBF), red blood cell (RBC) velocity and concentration due to CCD using laser-Doppler flowmetry (LDF) in awake mice. The ratio of the CCD side to the unaffected side in the cerebellum for CbBF 1 day after MCAO was decreased by -18% compared to baseline (before CCD). The ratio of the CCD side to the unaffected side for RBC concentration 1 day after MCAO was decreased by -23% compared to baseline. However, no significant changes in the ratio of the CCD side to the unaffected side were observed for RBC velocity. The present results indicate that the reduction of CbBF induced by neural deactivation was mainly caused by the decrease in RBC concentration. In contrast, our previous study showed that RBC velocity had a dominant role in the increase in cerebral blood flow (CBF) induced by neural activation. If RBC concentration can be considered an indicator of cerebral blood volume (CBV), hemodynamic changes due to neural activation and deactivation measured by LDF in mice might be in good agreement with human PET studies. | |||||
書誌情報 |
Brain Research 巻 1537, 号 6, p. 350-355, 発行日 2013-09 |
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出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0006-8993 | |||||
関連サイト | ||||||
識別子タイプ | DOI | |||||
関連識別子 | http://dx.doi.org/10.1016/j.brainres.2013.09.023 | |||||
関連名称 | http://dx.doi.org/10.1016/j.brainres.2013.09.023 |