@article{oai:repo.qst.go.jp:00047323,
 author = {Takuwa, Hiroyuki and Tajima, Yousuke and Kokuryo, Daisuke and Matsuura, Tetsuya and Kawaguchi, Hiroshi and Masamoto, Kazuto and Taniguchi, Jyunko and Ikoma, Yoko and Seki, Chie and Aoki, Ichio and Tomita, Yutaka and Suzuki, Norihiro and Kanno, Iwao and Ito, Hiroshi and 田桑 弘之 and 田島 洋佑 and 國領 大介 and 松浦 哲也 and 川口 拓之 and 正本 和人 and 谷口 順子 and 生駒 洋子 and 関 千江 and 青木 伊知男 and 冨田 裕 and 菅野 巖 and 伊藤 浩},
 issue = {6},
 journal = {Brain Research},
 month = {Sep},
 note = {Crossed cerebellar diaschisis (CCD) caused by contralateral supratentorial lesions can be considered a condition of neural deactivation, and hemodynamic changes in CCD were investigated with positron emission tomography (PET) in humans. In the present study, to investigate the effects of neural deactivation on hemodynamics, we developed a new mouse model of CCD, which was caused by middle cerebral artery occlusion (MCAO), and measured changes in cerebellar blood flow (CbBF), red blood cell (RBC) velocity and concentration due to CCD using laser-Doppler flowmetry (LDF) in awake mice. The ratio of the CCD side to the unaffected side in the cerebellum for CbBF 1 day after MCAO was decreased by -18% compared to baseline (before CCD). The ratio of the CCD side to the unaffected side for RBC concentration 1 day after MCAO was decreased by -23% compared to baseline. However, no significant changes in the ratio of the CCD side to the unaffected side were observed for RBC velocity. The present results indicate that the reduction of CbBF induced by neural deactivation was mainly caused by the decrease in RBC concentration. In contrast, our previous study showed that RBC velocity had a dominant role in the increase in cerebral blood flow (CBF) induced by neural activation. If RBC concentration can be considered an indicator of cerebral blood volume (CBV), hemodynamic changes due to neural activation and deactivation measured by LDF in mice might be in good agreement with human PET studies.},
 pages = {350--355},
 title = {Hemodynamic changes during neural deactivation in awake mice: A measurement by laser-Doppler flowmetry in crossed cerebellar diaschisis},
 volume = {1537},
 year = {2013}
}