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Neurobehavioral Changes in Mice Exposed to Fast Neutrons in utero
https://repo.qst.go.jp/records/47309
https://repo.qst.go.jp/records/473092aedfc4b-bd33-414c-b200-da8c4a4662db
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-09-17 | |||||
| タイトル | ||||||
| タイトル | Neurobehavioral Changes in Mice Exposed to Fast Neutrons in utero | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ishida, Yuka
× Ishida, Yuka× Ohmachi, Yasushi× Hiraoka, Takeshi× Nishikawa, Tetsu× Shimada, Yoshiya× Takai, Nobuhiko× Ogiu, Toshiaki× Nishimura, Yoshikazu× 石田 有香× 大町 康× 平岡 武× 西川 哲× 島田 義也× 高井 伸彦× 荻生 俊昭× 西村 義一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Epidemiological studies have revealed that radiation causes brain development abnormalities in atomic bomb survivors exposed in utero. Rat and mouse studies have also shown that prenatal exposure to low-linear energy transfer radiation induces developmental brain anomalies. Because the effects of prenatal irradiation on adult behavior patterns remain largely unknown, the present study investigated the effects of neutron exposure in utero on postnatal behavior patterns in mice. [C57BL/6JxC3H/He] hybrid (B6C3F1) mice were exposed to cyclotron-derived fast neutrons with peak energy of 10 MeV (0.02-0.2 Gy) or Cs-137 gamma-rays (0.2-1.5 Gy) on embryonic day 13.5. At 5.5-8 months of age, the neurobehavior of male offspring was examined by Rota-rod treadmill and locomotor activity. The accumulation of radio-labeled drug at muscarinic acetylcholine and serotonin receptors in mice from control and neutron-irradiated groups was determined by the tracer method. Locomotor activity during the dark period increased in the 0.02 Gy neutron-irradiated group. Furthermore, at 5.5 months of age, tracer binding in vivo to the muscarinic acetylcholine increased and to the serotonin receptors decreased in the 0.02 Gy neutron-irradiated group. In conclusion, the present study reveals that a certain "low-dose window" may exist for radiation-induced changes in neurobehavior and binding to neurotransmitter receptors, because there was correlation in neurobehavior and binding to neurotransmitter receptors in the 0.02 Gy neutron-irradiatedgroup though there was not correlation in the neutron-irradiated groups more than 0.05 Gy. |
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| 書誌情報 |
Journal of Radiation Research 巻 52, 号 3, p. 257-263, 発行日 2011-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
