@article{oai:repo.qst.go.jp:00047309,
 author = {Ishida, Yuka and Ohmachi, Yasushi and Hiraoka, Takeshi and Nishikawa, Tetsu and Shimada, Yoshiya and Takai, Nobuhiko and Ogiu, Toshiaki and Nishimura, Yoshikazu and 石田 有香 and 大町 康 and 平岡 武 and 西川 哲 and 島田 義也 and 高井 伸彦 and 荻生 俊昭 and 西村 義一},
 issue = {3},
 journal = {Journal of Radiation Research},
 month = {May},
 note = {Epidemiological studies have revealed that radiation causes brain development abnormalities in atomic bomb survivors exposed in utero. Rat and mouse studies have also shown that prenatal exposure to low-linear energy transfer radiation induces developmental brain anomalies. Because the effects of prenatal
irradiation on adult behavior patterns remain largely unknown, the present study investigated the effects of neutron exposure in utero on postnatal behavior patterns in mice. [C57BL/6JxC3H/He] hybrid (B6C3F1) mice were exposed to cyclotron-derived fast neutrons with peak energy of 10 MeV (0.02-0.2 Gy) or Cs-137 gamma-rays (0.2-1.5 Gy) on embryonic day 13.5. At 5.5-8 months of age, the neurobehavior
of male offspring was examined by Rota-rod treadmill and locomotor activity. The accumulation of radio-labeled drug at muscarinic acetylcholine and serotonin receptors in mice from control and neutron-irradiated groups was determined by the tracer method. Locomotor activity during the dark period increased in the 0.02 Gy neutron-irradiated group. Furthermore, at 5.5 months of age, tracer binding in vivo to the muscarinic acetylcholine increased and to the serotonin receptors decreased in the 0.02 Gy neutron-irradiated group. In conclusion, the present study reveals that a certain "low-dose window" may exist for radiation-induced changes in neurobehavior and binding to neurotransmitter receptors, because there was correlation in neurobehavior and binding to neurotransmitter receptors in the 0.02 Gy neutron-irradiatedgroup though there was not correlation in the neutron-irradiated groups more than 0.05 Gy.},
 pages = {257--263},
 title = {Neurobehavioral Changes in Mice Exposed to Fast Neutrons in utero},
 volume = {52},
 year = {2011}
}