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The differential role of human macrophage in triggering secondary bystander effects after either gamma-ray or carbon beam irradiation.
https://repo.qst.go.jp/records/47289
https://repo.qst.go.jp/records/47289542dcccb-4090-4362-85bf-d5eeca91a380
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-09-15 | |||||
| タイトル | ||||||
| タイトル | The differential role of human macrophage in triggering secondary bystander effects after either gamma-ray or carbon beam irradiation. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Dong, Chen
× Dong, Chen× He, Mingyuan× Tu, Wenzhi× Konishi, Teruaki× Liu, Weili× Xie, Yuexia× Dang, Bingrong× Li, Wenjian× Uchihori, Yukio× K., Hei Tom× Shao, Chunlin× 小西 輝昭× 内堀 幸夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The abscopal effect could be an underlying factor in evaluating prognosis of radiotherapy. This study established an in vitro system to examine whether tumor-generated bystander signals could be transmitted by macrophages to further trigger secondary cellular responses after different irradiations, where human lung cancer NCI-H446 cells were irradiated with either γ-rays or carbon ions and co-cultured with human macrophage U937 cells, then these U937 cells were used as a bystander signal transmitter and co-cultured with human bronchial epithelial cells BEAS-2B. Results showed that U937 cells were only activated by γ-irradiated NCI-H446 cells so that the secondary injuries in BEAS-2B cells under carbon ion irradiation were weaker than γ-rays. Both TNF-α and IL-1α were involved in γ-irradiation induced secondary bystander effect but only TNF-α contributed to the carbon ion induced response. Further assay disclosed that IL-1α but not TNF-α was largely responsible for the activation of macrophages and the formation of micronucleus in BEAS-2B cells. These data suggest that macrophages could transfer secondary bystander signals and play a key role in the secondary bystander effect of photon irradiation while carbon ion irradiation has conspicuous advantage due to its reduced secondary injury. | |||||
| 書誌情報 |
Cancer Letters 巻 363, 号 1, p. 92-100, 発行日 2015-04 |
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| 出版者 | ||||||
| 出版者 | Elsevier Inc. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0304-3835 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 25896631 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.canlet.2015.04.013 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.cancerletters.info/article/S0304-3835%2815%2900281-5/pdf | |||||
| 関連名称 | http://www.cancerletters.info/article/S0304-3835%2815%2900281-5/pdf | |||||
