{"created":"2023-05-15T14:36:42.489454+00:00","id":47289,"links":{},"metadata":{"_buckets":{"deposit":"4839c2f5-58f4-4164-810e-0059fcd6bdeb"},"_deposit":{"created_by":1,"id":"47289","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47289"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047289","sets":["1"]},"author_link":["472990","472988","472992","472994","472991","472989","472993","472984","472986","472985","472983","472982","472987"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"100","bibliographicPageStart":"92","bibliographicVolumeNumber":"363","bibliographic_titles":[{"bibliographic_title":"Cancer Letters"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The abscopal effect could be an underlying factor in evaluating prognosis of radiotherapy. This study established an in vitro system to examine whether tumor-generated bystander signals could be transmitted by macrophages to further trigger secondary cellular responses after different irradiations, where human lung cancer NCI-H446 cells were irradiated with either γ-rays or carbon ions and co-cultured with human macrophage U937 cells, then these U937 cells were used as a bystander signal transmitter and co-cultured with human bronchial epithelial cells BEAS-2B. Results showed that U937 cells were only activated by γ-irradiated NCI-H446 cells so that the secondary injuries in BEAS-2B cells under carbon ion irradiation were weaker than γ-rays. Both TNF-α and IL-1α were involved in γ-irradiation induced secondary bystander effect but only TNF-α contributed to the carbon ion induced response. Further assay disclosed that IL-1α but not TNF-α was largely responsible for the activation of macrophages and the formation of micronucleus in BEAS-2B cells. These data suggest that macrophages could transfer secondary bystander signals and play a key role in the secondary bystander effect of photon irradiation while carbon ion irradiation has conspicuous advantage due to its reduced secondary injury.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Inc. "}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"25896631","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.canlet.2015.04.013","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.cancerletters.info/article/S0304-3835%2815%2900281-5/pdf"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.cancerletters.info/article/S0304-3835%2815%2900281-5/pdf","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0304-3835","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Dong, Chen"}],"nameIdentifiers":[{"nameIdentifier":"472982","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"He, Mingyuan"}],"nameIdentifiers":[{"nameIdentifier":"472983","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tu, Wenzhi"}],"nameIdentifiers":[{"nameIdentifier":"472984","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Konishi, Teruaki"}],"nameIdentifiers":[{"nameIdentifier":"472985","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Liu, Weili"}],"nameIdentifiers":[{"nameIdentifier":"472986","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Xie, Yuexia"}],"nameIdentifiers":[{"nameIdentifier":"472987","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Dang, Bingrong"}],"nameIdentifiers":[{"nameIdentifier":"472988","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Li, Wenjian"}],"nameIdentifiers":[{"nameIdentifier":"472989","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uchihori, Yukio"}],"nameIdentifiers":[{"nameIdentifier":"472990","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"K., Hei Tom"}],"nameIdentifiers":[{"nameIdentifier":"472991","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shao, Chunlin"}],"nameIdentifiers":[{"nameIdentifier":"472992","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小西 輝昭","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"472993","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"内堀 幸夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"472994","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The differential role of human macrophage in triggering secondary bystander effects after either gamma-ray or carbon beam irradiation.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The differential role of human macrophage in triggering secondary bystander effects after either gamma-ray or carbon beam irradiation."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-09-15"},"publish_date":"2015-09-15","publish_status":"0","recid":"47289","relation_version_is_last":true,"title":["The differential role of human macrophage in triggering secondary bystander effects after either gamma-ray or carbon beam irradiation."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:41:34.599084+00:00"}