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The simple preparation of polyethylene glycol-based soft nanoparticles containing dual imaging probes
https://repo.qst.go.jp/records/47264
https://repo.qst.go.jp/records/47264657965bb-bdfc-483c-840f-93a22e709955
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-19 | |||||
| タイトル | ||||||
| タイトル | The simple preparation of polyethylene glycol-based soft nanoparticles containing dual imaging probes | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Murayama, Shuhei
× Murayama, Shuhei× Jo, Jun-ichiro× Kun, Liang× Saga, Tsuneo× Aoki, Ichio× Kato, Masaru× et.al× 村山 周平× 城 潤一郎× クン リアン× 佐賀 恒夫× 青木 伊知男× 加藤 大 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We developed a simple method to prepare PEG-based soft nanoparticles that encapsulate dual imaging probes. Because the probes could be encapsulated by either chemical or physical means, a variety of probe molecules were encapsulated within the nanoparticles simultaneously. The nanoparticles were administrated to mice and the pharmacokinetics of the nanoparticles was analyzed by means of MRI, fluorescence spectroscopy, and transmission electron microscopy. The soft nanoparticles were excreted by the mice rapidly through the urine without collapse of the nanoparticles and without leaking of the probe molecules, and no accumulation of the nanoparticles in the body was observed. The pharmacokinetics of the nanoparticles was not changed by the encapsulated molecules and acute toxicity to mice was negligible. It was expect that these PEG-based soft nanoparticles will be applicable for use as a safe diagnostic agent. | |||||
| 書誌情報 |
Journal of Materials Chemistry B 巻 1, 号 38, p. 4932-4938, 発行日 2013-07 |
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| 出版者 | ||||||
| 出版者 | Royal Society of Chemistry | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2050-750X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1039/c3tb20828a | |||||
