@article{oai:repo.qst.go.jp:00047264,
 author = {Murayama, Shuhei and Jo, Jun-ichiro and Kun, Liang and Saga, Tsuneo and Aoki, Ichio and Kato, Masaru and et.al and 村山 周平 and 城 潤一郎 and クン リアン and 佐賀 恒夫 and 青木 伊知男 and 加藤 大},
 issue = {38},
 journal = {Journal of Materials Chemistry B},
 month = {Jul},
 note = {We developed a simple method to prepare PEG-based soft nanoparticles that encapsulate dual imaging probes. Because the probes could be encapsulated by either chemical or physical means, a variety of probe molecules were encapsulated within the nanoparticles simultaneously. The nanoparticles were administrated to mice and the pharmacokinetics of the nanoparticles was analyzed by means of MRI, fluorescence spectroscopy, and transmission electron microscopy. The soft nanoparticles were excreted by the mice rapidly through the urine without collapse of the nanoparticles and without leaking of the probe molecules, and no accumulation of the nanoparticles in the body was observed. The pharmacokinetics of the nanoparticles was not changed by the encapsulated molecules and acute toxicity to mice was negligible. It was expect that these PEG-based soft nanoparticles will be applicable for use as a safe diagnostic agent.},
 pages = {4932--4938},
 title = {The simple preparation of polyethylene glycol-based soft nanoparticles containing dual imaging probes},
 volume = {1},
 year = {2013}
}