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Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment-dementia converter measured by positron emission tomography with [11C]DAA1106.
https://repo.qst.go.jp/records/47238
https://repo.qst.go.jp/records/472388b9244cf-bede-4e8e-8635-af3fb86ae95a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-07 | |||||
| タイトル | ||||||
| タイトル | Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment-dementia converter measured by positron emission tomography with [11C]DAA1106. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yasuno, Fumihiko
× Yasuno, Fumihiko× Kosaka, Jun× Ota, Miho× Higuchi, Makoto× Ito, Hiroshi× Fujimura, Yota× Nozaki, Syoko× Takahashi, Sho× Mizukami, Katsuyoshi× Asada, Takashi× Suhara, Tetsuya× 安野 史彦× 小坂 淳× 太田 深秀× 樋口 真人× 伊藤 浩× 藤村 洋太× 野崎 昭子× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Subjects with mild cognitive impairment (MCI) have [prodromal or incipient] dementia with neuropathological changes. Peripheral benzodiazepine receptor (PBR) binding was shown to reflect activated microglia, one of the predictive biomarkers of conversion to dementia.We sought to evaluate PBR binding inMCI subjects using positron emission tomography (PET). PET scanswith [11C]DAA1106, a potent and selective ligand for PBR, were performed on seven MCI subjects, 10 patients with Alzheimer's disease (AD) and 10 age-matched control subjects. PBR binding in the regions of interest was quantified by binding potential (BP). FiveMCI subjects were clinically followed for 5 years after their initial PET scans. [11C]DAA1106 binding to PBR was significantly increased in widespread areas in MCI subjects when compared to healthy controls. We found no significant difference in BP between MCI and AD patients. MCI subjects with [11C]DAA1106 binding values higher than the control mean +0.5 standard deviation (S.D.) developed dementia within 5 years. Our finding of higher DAA binding in MCI subjects indicated that microglial activation may occur before the onset of dementia. In vivo detection of microglial activation may provide useful prognostic information with respect to stratifyingMCI subjects at increased risk of dementia. |
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| 書誌情報 |
Psychiatry Research 巻 203, 号 1, p. 67-74, 発行日 2012-07 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0165-1781 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 22892349 | |||||
