@article{oai:repo.qst.go.jp:00047238,
 author = {Yasuno, Fumihiko and Kosaka, Jun and Ota, Miho and Higuchi, Makoto and Ito, Hiroshi and Fujimura, Yota and Nozaki, Syoko and Takahashi, Sho and Mizukami, Katsuyoshi and Asada, Takashi and Suhara, Tetsuya and 安野 史彦 and 小坂 淳 and 太田 深秀 and 樋口 真人 and 伊藤 浩 and 藤村 洋太 and 野崎 昭子 and 須原 哲也},
 issue = {1},
 journal = {Psychiatry Research},
 month = {Jul},
 note = {Subjects with mild cognitive impairment (MCI) have [prodromal or incipient] dementia with neuropathological changes. Peripheral benzodiazepine receptor (PBR) binding was shown to reflect activated microglia, one of the predictive biomarkers of conversion to dementia.We sought to evaluate PBR binding inMCI subjects using positron emission tomography (PET). PET scanswith [11C]DAA1106, a potent and selective ligand for PBR, were performed on seven MCI subjects, 10 patients with Alzheimer's disease (AD) and 10 age-matched control subjects.
PBR binding in the regions of interest was quantified by binding potential (BP). FiveMCI subjects were clinically followed for 5 years after their initial PET scans. [11C]DAA1106 binding to PBR was significantly increased in widespread areas in MCI subjects when compared to healthy controls. We found no significant difference in BP between MCI and AD patients. MCI subjects with [11C]DAA1106 binding values higher than the control mean +0.5 standard deviation (S.D.) developed dementia within 5 years. Our finding of higher DAA binding in MCI subjects indicated that microglial activation may occur before the onset of dementia. In vivo detection of microglial activation may provide useful prognostic information with respect to stratifyingMCI subjects at increased risk of dementia.},
 pages = {67--74},
 title = {Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment-dementia converter measured by positron emission tomography with [11C]DAA1106.},
 volume = {203},
 year = {2012}
}