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Striatal and extrastriatal dopamine D2 receptor occupancy by the partial agonist antipsychotic drug aripiprazole in the human brain: a positron emission tomography study with [11C]raclopride and [11C]FLB457
https://repo.qst.go.jp/records/47231
https://repo.qst.go.jp/records/472312a82fb67-8cb9-4744-914a-a7eb3a92c26f
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-08-06 | |||||
タイトル | ||||||
タイトル | Striatal and extrastriatal dopamine D2 receptor occupancy by the partial agonist antipsychotic drug aripiprazole in the human brain: a positron emission tomography study with [11C]raclopride and [11C]FLB457 | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Takahata, Keisuke
× Takahata, Keisuke× Ito, Hiroshi× Takano, Harumasa× Arakawa, Ryosuke× Fujiwara, Hironobu× Kimura, Yasuyuki× Kodaka, Fumitoshi× Sasaki, Takeshi× Nogami, Tsuyoshi× Suzuki, Masayuki× Nagashima, Tomohisa× Shimada, Hitoshi× Kato, Motoichiro× Mimura, Masaru× Suhara, Tetsuya× 高畑 圭輔× 伊藤 浩× 高野 晴成× 荒川 亮介× 藤原 広臨× 木村 泰之× 小高 文聰× 佐々木 健至× 野上 毅× 鈴木 雅之× 永嶌 朋久× 島田 斉× 加藤 元一郎× 三村 將× 須原 哲也 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Rationale Second-generation antipsychotics demonstrate clinical efficacy with fewer extrapyramidal side effects compared with first-generation antipsychotics. One of the proposed explanations is the hypothesis of preferential extrastriatal dopamine D2 receptor occupancy (limbic selectivity) by antipsychotics. In the present study, we focused on aripiprazole, which has a unique pharmacological profile with partial agonismat dopamineD2 receptors and the minimal risk of extrapyramidal side effects. Previous positron emission tomography (PET) studies using high-affinity radioligands for dopamine D2 receptors have reported inconsistent results regarding regional differences of dopamine D2 receptor occupancy by aripiprazole. |
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書誌情報 |
Psychopharmacology 巻 222, 号 1, p. 165-172, 発行日 2012-07 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0033-3158 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 22237854 |