@article{oai:repo.qst.go.jp:00047231,
 author = {Takahata, Keisuke and Ito, Hiroshi and Takano, Harumasa and Arakawa, Ryosuke and Fujiwara, Hironobu and Kimura, Yasuyuki and Kodaka, Fumitoshi and Sasaki, Takeshi and Nogami, Tsuyoshi and Suzuki, Masayuki and Nagashima, Tomohisa and Shimada, Hitoshi and Kato, Motoichiro and Mimura, Masaru and Suhara, Tetsuya and 高畑 圭輔 and 伊藤 浩 and 高野 晴成 and 荒川 亮介 and 藤原 広臨 and 木村 泰之 and 小高 文聰 and 佐々木 健至 and 野上 毅 and 鈴木 雅之 and 永嶌 朋久 and 島田 斉 and 加藤 元一郎 and 三村 將 and 須原 哲也},
 issue = {1},
 journal = {Psychopharmacology},
 month = {Jul},
 note = {Rationale Second-generation antipsychotics demonstrate
clinical efficacy with fewer extrapyramidal side effects compared
with first-generation antipsychotics. One of the proposed
explanations is the hypothesis of preferential
extrastriatal dopamine D2 receptor occupancy (limbic selectivity)
by antipsychotics. In the present study, we focused on
aripiprazole, which has a unique pharmacological profile with
partial agonismat dopamineD2 receptors and the minimal risk
of extrapyramidal side effects. Previous positron emission
tomography (PET) studies using high-affinity radioligands
for dopamine D2 receptors have reported inconsistent results
regarding regional differences of dopamine D2 receptor occupancy
by aripiprazole.},
 pages = {165--172},
 title = {Striatal and extrastriatal dopamine D2 receptor occupancy by the partial agonist antipsychotic drug aripiprazole in the human brain: a positron emission tomography study with [11C]raclopride and [11C]FLB457},
 volume = {222},
 year = {2012}
}