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Occupancy of serotonin and norepinephrine transporter by milnacipran in patients with major depressive disorder: a positron emission tomography study with [11C]DASB and (S,S)-[18F]FMeNER-D2.
https://repo.qst.go.jp/records/47220
https://repo.qst.go.jp/records/472205fdb0a67-63cb-4ba9-b950-77be17aa82d8
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-06 | |||||
| タイトル | ||||||
| タイトル | Occupancy of serotonin and norepinephrine transporter by milnacipran in patients with major depressive disorder: a positron emission tomography study with [11C]DASB and (S,S)-[18F]FMeNER-D2. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nogami, Tsuyoshi
× Nogami, Tsuyoshi× Takano, Harumasa× Arakawa, Ryosuke× Ichimiya, Tetsuya× Fujiwara, Hironobu× Kimura, Yasuyuki× Kodaka, Fumitoshi× Sasaki, Takeshi× Takahata, Keisuke× Suzuki, Masayuki× Nagashima, Tomohisa× Mori, Takaaki× Shimada, Hitoshi× Fukuda, Hajime× Sekine, Mizuho× Tateno, Amane× Takahashi, Hidehiko× Ito, Hiroshi× Okubo, Yoshiro× Suhara, Tetsuya× 野上 毅× 高野 晴成× 荒川 亮介× 一宮 哲哉× 藤原 広臨× 木村 泰之× 小高 文聰× 佐々木 健至× 高畑 圭輔× 鈴木 雅之× 永嶌 朋久× 森 崇明× 島田 斉× 関根 瑞保× 舘野 周× 高橋 英彦× 伊藤 浩× 大久保 善朗× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Antidepressants used for treatment of depression exert their efficacy by blocking reuptake at serotonin transporters (5-HTT) and/or norepinephrine transporters (NET). Recent studies suggest that serotonin and norepinephrine reuptake inhibitors that block both 5-HTT and NET have better tolerability than tricyclic antidepressants and may have higher efficacy compared to selective serotonin reuptake inhibitors. Previous positron emission tomography (PET) studies have reported >80% 5-HTT occupancy with clinical doses of antidepressants, but there has been no report of NET occupancy in patients treated with antidepressants. In the present study, we investigated both 5-HTT and NET occupancies by PET using radioligands [11C]DASB and (S,S)-[18F]FMeNER-D2, in six patients, each with major depressive disorder (MDD), using various doses of milnacipran. Our data show that mean 5-HTT occupancy in the thalamus was 33.0% at 50?mg, 38.6% at 100?mg, 60.0% at 150?mg and 61.5% at 200?mg. Mean NET occupancy in the thalamus was 25.3% at 25?mg, 40.0% at 100?mg, 47.3% at 125?mg and 49.9% at 200?mg. Estimated ED50 was 122.5?mg with the dose for 5-HTT and 149.9?mg for NET. Both 5-HTT and NET occupancies were observed in a dose-dependent manner. Both 5-HTT and NET occupancies were about 40% by milnacipran at 100?mg, the dose most commonly administered to MDD patients. | |||||
| 書誌情報 |
The International Journal of Neuropsychopharmacology 巻 16, 号 5, p. 937-943, 発行日 2012-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1461-1457 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 23067569 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8715686 | |||||
| 関連名称 | http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8715686 | |||||
