{"created":"2023-05-15T14:36:39.458906+00:00","id":47220,"links":{},"metadata":{"_buckets":{"deposit":"17384291-4750-4af5-b3c2-e0cd0e02f686"},"_deposit":{"created_by":1,"id":"47220","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47220"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047220","sets":["1"]},"author_link":["472097","472101","472098","472093","472096","472100","472084","472074","472076","472077","472070","472081","472090","472091","472072","472103","472104","472067","472102","472094","472099","472086","472075","472078","472087","472071","472073","472069","472079","472089","472085","472083","472068","472088","472080","472082","472092","472095","472066"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"943","bibliographicPageStart":"937","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"The International Journal of Neuropsychopharmacology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Antidepressants used for treatment of depression exert their efficacy by blocking reuptake at serotonin transporters (5-HTT) and/or norepinephrine transporters (NET). Recent studies suggest that serotonin and norepinephrine reuptake inhibitors that block both 5-HTT and NET have better tolerability than tricyclic antidepressants and may have higher efficacy compared to selective serotonin reuptake inhibitors. Previous positron emission tomography (PET) studies have reported >80% 5-HTT occupancy with clinical doses of antidepressants, but there has been no report of NET occupancy in patients treated with antidepressants. In the present study, we investigated both 5-HTT and NET occupancies by PET using radioligands [11C]DASB and (S,S)-[18F]FMeNER-D2, in six patients, each with major depressive disorder (MDD), using various doses of milnacipran. Our data show that mean 5-HTT occupancy in the thalamus was 33.0% at 50?mg, 38.6% at 100?mg, 60.0% at 150?mg and 61.5% at 200?mg. Mean NET occupancy in the thalamus was 25.3% at 25?mg, 40.0% at 100?mg, 47.3% at 125?mg and 49.9% at 200?mg. Estimated ED50 was 122.5?mg with the dose for 5-HTT and 149.9?mg for NET. Both 5-HTT and NET occupancies were observed in a dose-dependent manner. Both 5-HTT and NET occupancies were about 40% by milnacipran at 100?mg, the dose most commonly administered to MDD patients.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"23067569","subitem_relation_type_select":"PMID"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8715686"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8715686","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1461-1457","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only 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(S,S)-[18F]FMeNER-D2."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-08-06"},"publish_date":"2015-08-06","publish_status":"0","recid":"47220","relation_version_is_last":true,"title":["Occupancy of serotonin and norepinephrine transporter by milnacipran in patients with major depressive disorder: a positron emission tomography study with [11C]DASB and (S,S)-[18F]FMeNER-D2."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:42:27.588243+00:00"}