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Four-dimensional treatment planning in layer-stacking boost irradiation for carbon-ion pancreatic therapy
https://repo.qst.go.jp/records/47175
https://repo.qst.go.jp/records/47175397ce1b7-a228-430c-b29d-b235943a524f
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-07-23 | |||||
| タイトル | ||||||
| タイトル | Four-dimensional treatment planning in layer-stacking boost irradiation for carbon-ion pancreatic therapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Mori, Shinichiro
× Mori, Shinichiro× Shinoto, Makoto× Yamada, Shigeru× 森 慎一郎× 山田 滋 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: We evaluated respiratory-gated carbon-ion beam dose distribution with boost irradiation in pancreatic therapy and compared results between the passive scattering and layer-stacking (a kind of semi-active scanning) irradiation techniques. Materials and Methods: A total of 21 patients who were treated with conventional passive carbon-ion beam for pancreatic cancer underwent 4DCT imaging under free-breathing conditions. We defined two types of clinical target volume (CTV) for the initial and boost irradiations: CTV1 included the gross tumor volume (GTV) and peripheral organs, and CTV2 included the GTV only with an added uniform 2-mm margin. Planning target volumes 1 and 2 (PTV1 and PTV2) were calculated by adding the range variation considered internal margin defined by 4DCT to the respective CTVs. The initial prescribed dose (= 45.6Gy(RBE); RBE-weighted absorbed dose) was given to PTV1, and the boost dose was increased up to 26.4Gy(RBE) and given to PTV2. Dose assessments were compared between irradiation techniques using the paired t-test. Results: D95(GTV, CTV2) values were increased from 44.2Gy(RBE) with the prescribed dose of 45.6Gy(RBE) to 69.8Gy(RBE) with the prescribed dose of 72.0Gy(RBE) with both irradiations. Layer-stacking irradiation reduced excessive dosing to normal tissues compared with passive scattering irradiation, particularly for boost irradiation. 1st-2nd portion V20/V40, and stomach V20 values up to the prescribed dose of 48.0, 60.0, and 52.8Gy(RBE) were smaller than those in passive scattering irradiation without boost. Kidney V15/V30 (0.6%(P=0.05)/0.1%(P>0.20) for right kidney, 10.4%(P<0.01)/3.2%(P<0.01) for left kidney), pancreas V20/V40 (88.6%(P<0.01)/83.0%(P<0.03)), duodenum 3rd-4th portion V20/V40 (23.6%(P<0.01)/9.5%(P>0.06)), and stomach V20 (16.3%(P<0.01)) values in layer-stacking irradiation were smaller than those in passive scattering irradiation up to the prescribed dose of 72.0Gy(RBE) and also smaller than those with passive scattering irradiation without boost irradiation (= 45.6Gy(RBE)). Conclusions: In pancreatic particle beam therapy, delivery of the prescribed dose by layer-stacking boost irradiation provides a greater reduction in excessive dose to normal tissues than delivery by passive scattering irradiation. |
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| 書誌情報 |
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 巻 111, 号 2, p. 258-263, 発行日 2014-05 |
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| 出版者 | ||||||
| 出版者 | Elsevier Scientific Publishers | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0167-8140 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.1016/j.radonc.2014.02.014 | |||||
