{"created":"2023-05-15T14:36:37.495387+00:00","id":47175,"links":{},"metadata":{"_buckets":{"deposit":"438f0ab0-5002-4b23-a682-36e5de1ed418"},"_deposit":{"created_by":1,"id":"47175","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47175"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047175","sets":["1"]},"author_link":["471435","471434","471433","471432","471431"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"263","bibliographicPageStart":"258","bibliographicVolumeNumber":"111","bibliographic_titles":[{"bibliographic_title":"Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: We evaluated respiratory-gated carbon-ion beam dose distribution with boost irradiation in pancreatic therapy and compared results between the passive scattering and layer-stacking (a kind of semi-active scanning) irradiation techniques.\nMaterials and Methods: A total of 21 patients who were treated with conventional passive carbon-ion beam for pancreatic cancer underwent 4DCT imaging under free-breathing conditions. We defined two types of clinical target volume (CTV) for the initial and boost irradiations: CTV1 included the gross tumor volume (GTV) and peripheral organs, and CTV2 included the GTV only with an added uniform 2-mm margin. Planning target volumes 1 and 2 (PTV1 and PTV2) were calculated by adding the range variation considered internal margin defined by 4DCT to the respective CTVs. The initial prescribed dose (= 45.6Gy(RBE); RBE-weighted absorbed dose) was given to PTV1, and the boost dose was increased up to 26.4Gy(RBE) and given to PTV2. Dose assessments were compared between irradiation techniques using the paired t-test.\nResults: D95(GTV, CTV2) values were increased from 44.2Gy(RBE) with the prescribed dose of 45.6Gy(RBE) to 69.8Gy(RBE) with the prescribed dose of 72.0Gy(RBE) with both irradiations. Layer-stacking irradiation reduced excessive dosing to normal tissues compared with passive scattering irradiation, particularly for boost irradiation. 1st-2nd portion V20/V40, and stomach V20 values up to the prescribed dose of 48.0, 60.0, and 52.8Gy(RBE) were smaller than those in passive scattering irradiation without boost. Kidney V15/V30 (0.6%(P=0.05)/0.1%(P>0.20) for right kidney, 10.4%(P<0.01)/3.2%(P<0.01) for left kidney), pancreas V20/V40 (88.6%(P<0.01)/83.0%(P<0.03)), duodenum 3rd-4th portion V20/V40 (23.6%(P<0.01)/9.5%(P>0.06)), and stomach V20 (16.3%(P<0.01)) values in layer-stacking irradiation were smaller than those in passive scattering irradiation up to the prescribed dose of 72.0Gy(RBE) and also smaller than those with passive scattering irradiation without boost irradiation (= 45.6Gy(RBE)).\nConclusions: In pancreatic particle beam therapy, delivery of the prescribed dose by layer-stacking boost irradiation provides a greater reduction in excessive dose to normal tissues than delivery by passive scattering irradiation.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Scientific Publishers"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1016/j.radonc.2014.02.014","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0167-8140","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mori, Shinichiro"}],"nameIdentifiers":[{"nameIdentifier":"471431","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinoto, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"471432","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Shigeru"}],"nameIdentifiers":[{"nameIdentifier":"471433","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森 慎一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"471434","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 滋","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"471435","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Four-dimensional treatment planning in layer-stacking boost irradiation  for carbon-ion pancreatic therapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Four-dimensional treatment planning in layer-stacking boost irradiation  for carbon-ion pancreatic therapy"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-07-23"},"publish_date":"2015-07-23","publish_status":"0","recid":"47175","relation_version_is_last":true,"title":["Four-dimensional treatment planning in layer-stacking boost irradiation  for carbon-ion pancreatic therapy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:43:02.181165+00:00"}