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Dendrimeric calcium-responsive MRI contrast agents with slow in vivo diffusion
https://repo.qst.go.jp/records/47111
https://repo.qst.go.jp/records/47111009fce03-0087-4067-a62b-cc1f4d34d673
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-04-27 | |||||
| タイトル | ||||||
| タイトル | Dendrimeric calcium-responsive MRI contrast agents with slow in vivo diffusion | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Gündüz, Serhat
× Gündüz, Serhat× Nitta, Nobuhiro× Vibhute, Sandip× Shibata, Sayaka× Martin, E. Mayer× Nikos K. Logothetis× Aoki, Ichio× Angelovski, Goran× 新田 展大× 柴田 さやか× 青木 伊知男 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We report a methodology which enables the preparation of dendrimeric contrast agents sensitive to Ca2+ when starting from the monomeric analogue. The Ca-triggered longitudinal relaxivity response of these agents is not compromised by undertaking synthetic transformations, despite structural changes. The in vivo MRI studies in the rat cerebral cortex indicate that diffusion properties of dendrimeric contrast agents have great advantages as compared to their monomeric equivalents. | |||||
| 書誌情報 |
Chemical Communications 巻 14, p. 2782-2785, 発行日 2014-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1359-7345 | |||||
