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Quantitative Analysis of Amyloid Deposition in Alzheimer Disease Using PET and the Radiotracer 11C-AZD2184.
https://repo.qst.go.jp/records/47103
https://repo.qst.go.jp/records/47103d615ed49-8045-40f7-8973-16f2bc5ad3a5
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-04-20 | |||||
| タイトル | ||||||
| タイトル | Quantitative Analysis of Amyloid Deposition in Alzheimer Disease Using PET and the Radiotracer 11C-AZD2184. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ito, Hiroshi
× Ito, Hiroshi× Shimada, Hitoshi× Shinotoh, Hitoshi× Takano, Harumasa× Sasaki, Takeshi× Nogami, Tsuyoshi× Suzuki, Masayuki× Nagashima, Tomohisa× Takahata, Keisuke× Seki, Chie× Kodaka, Fumitoshi× Eguchi, Yoko× Fujiwara, Hironobu× Kimura, Yasuyuki× Hirano, Shigeki× Ikoma, Yoko× Higuchi, Makoto× Kawamura, Kazunori× Fukumura, Toshimitsu× Lindström, Böö Eva× Farde, Lars× Suhara, Tetsuya× 伊藤 浩× 島田 斉× 篠遠 仁× 高野 晴成× 佐々木 健至× 野上 毅× 鈴木 雅之× 永嶌 朋久× 高畑 圭輔× 関 千江× 小高 文聰× 江口 洋子× 藤原 広臨× 木村 泰之× 平野 成樹× 生駒 洋子× 樋口 真人× 河村 和紀× 福村 利光× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Characteristic neuropathologic changes in Alzheimer disease (AD) are amyloid-β deposits and neurofibrillary tangles. Recently, a new radioligand for amyloid senile plaques, (11)C-labeled 5-(6-{[tert-butyl(dimethyl)silyl]oxy}-1,3-benzothiazol-2-yl)pyridin-2-amine ((11)C-AZD2184), was developed, and it was reported to show rapid brain uptake followed by rapid washout. In this study, (11)C-AZD2184 binding in control subjects and AD patients was examined in more detail by compartment model analysis using a metabolite-corrected arterial input function. The accuracy of simplified quantitative methods using a reference brain region was also evaluated. | |||||
| 書誌情報 |
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 巻 55, 号 6, p. 932-938, 発行日 2014-04 |
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| 出版者 | ||||||
| 出版者 | Society of Nuclear Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0161-5505 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 24732152 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.2967/jnumed.113.133793 | |||||
