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Biodistribution and radiation dosimetry in humans of [11C]FLB 457, a positron emission tomography ligand for the extrastriatal dopamine D2 receptor
https://repo.qst.go.jp/records/47096
https://repo.qst.go.jp/records/470962f0913bd-4371-460e-8ff0-93192be25786
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-04-20 | |||||
| タイトル | ||||||
| タイトル | Biodistribution and radiation dosimetry in humans of [11C]FLB 457, a positron emission tomography ligand for the extrastriatal dopamine D2 receptor | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kimura, Yasuyuki
× Kimura, Yasuyuki× Ito, Hiroshi× Shiraishi, Takahiro× Fujiwara, Hironobu× Kodaka, Fumitoshi× Takano, Harumasa× Shimada, Hitoshi× Kanno, Iwao× Suhara, Tetsuya× 木村 泰之× 伊藤 浩× 白石 貴博× 藤原 広臨× 小高 文聰× 高野 晴成× 島田 斉× 菅野 巖× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Abstract: Purpose: [11C]FLB 457, a radioligand with very high affinity and selectivity for dopamine D2/3 receptors, is used to measure receptor binding in extrastriatal regions showing low density of the receptors. The purpose of this study was to estimate the whole-body biodistribution of radioactivity and the radiation absorbed doses to organs after intravenous injection of [11C]FLB 457 in healthy human subjects. Methods: Whole-body images were acquired for 2 h after an injection of [11C]FLB 457 in six healthy humans. Radiation absorbed doses were estimated by the MIRD scheme implemented in OLINDA/EXM 1.1 software. Results: Organs with the longest residence time were the liver, lungs, and red marrow. The organs with the highest radiation doses were the kidneys, liver, and pancreas. The effective dose delivered by [11C]FLB 457 is 5.9 microSv/MBq, similar to those of other 11C-labeled tracers. Conclusions: This effective dose would allow multiple scans in the same individual based on prevailing maximum recommended- dose guidelines in the USA and Europe. |
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| 書誌情報 |
Nuclear Medicine and Biology 巻 41, 号 1, p. 102-105, 発行日 2013-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0969-8051 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 24075253 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.nucmedbio.2013.08.008 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.sciencedirect.com/science/article/pii/S0969805113001753 | |||||
| 関連名称 | http://www.sciencedirect.com/science/article/pii/S0969805113001753 | |||||
